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This chapter contains a discussion of interdependencies as an explanatory construct in conceptualising the business world and explaining managerial behaviours. Specific interdependencies that exist in business networks influence the outcomes of business relationships. Such interdependencies can be more or less clearly acknowledged and perceived by the practitioners (managers), who can act upon them and create new interdependencies. Interdependence thus also plays an important role in developing effective explanations and conceptualisations of the business world. Some of the interdependencies are consequences of actions focusing on rationalisations, development or positioning, while other interdependencies are made with the intention of creating a specific position or some other effects. To live with, and be competent in, handling interdependencies is thus imperative in the interactive business landscape; as a consequence interdependencies need to be addressed when theorising the business world and its dynamics.