Search results

The purpose of this paper is to analyze the influence of curvature on the transport of low-density lipoprotein (LDL) through a curved artery and concentration boundary layer characteristics numerically.

By using a projection method based on the second-order central difference discretization, the authors solve the set of governing equations, which consists of Navier–Stokes, continuity and species transport. The effects of initial straight length, as well as the curvature and wall shear stress (WSS) on LDL transport in a curved artery are established in this paper.

The obtained numerical results imply that the LDL concentration boundary layer thickness decreases in the outer part of the curved artery and increases in the inner part for both with or without initial straight length. The effect of Reynolds number on the concentration distribution in a curved artery with initial straight length is more pronounced than that on a fully curved artery, although an opposite trend was seen for the curvature ratio. The maximum surface LDL concentration is related to the regions with minimum WSS in the inner part of the curved artery, which has more potential the formation of atherosclerosis.

The authors present a comprehensive concentration distribution of LDL in the concentration boundary layer of the curved artery. The authors also characterize and predict the influence of curvature on the formation and development of atherosclerosis within the arterial wall.

The purpose of this study is to analyze the two-dimensional blood flow in the artery slant from the axis at an angle with mild stenosis under the joint effects of the electro-osmotic, magnetic field, chemical reaction and porosity using a new analytical method. In addition, the mathematical model presented by the researchers Tripathi and Sharma (2018c) was successfully developed by adding the effect of electro-osmosis and studying the impact of the new addition in the developed model on blood flow.

A new analytical method was used to find the analytical approximate solutions of two-dimensional blood flow in artery slant from the axis at an angle with mild stenosis. This technique is based on integrating the Akbari-Ganji and the homotopy perturbation methods.

The results of axial velocity, concentration, temperature and the wall shear stress for blood flow were analyzed in the cases of the absence and presence of electro-osmosis. Furthermore, in these two states of electro-osmosis, a contour plot was created to show the difference in the profile of velocity to the flow of blood when the magnetic field was increased and the altitude of stenosis was increased. The results showed that the new technique is effective and has high accuracy to determine the analytical approximate solutions of two-dimensional blood flow in artery slant from the axis at an angle with mild stenosis. The validity, utility and necessity of the new method were illustrated from the graphs of the new solutions; in addition, there is an excellent agreement with the results of previous studies.

This paper focuses on developing the mathematical model which was presented by the researchers Tripathi and Sharma (2018c), by adding the effect of the electro-osmosis to it, which has been successfully developed. According to the authors’ modest information, the new system has not been studied before. This current problem is solved by using an innovative approach known as the Akbari-Ganji homotopy perturbation method (AGHPM) which has not been used before in two cases: the presence and absence of the effect of electro-osmosis. This new technique afford new with effective and has high accuracy results. Furthermore, the new study (i.e. adding effect of electro-osmosis) with the applications of (variable viscosity, magnetic field, chemical reaction and porosity) illustrated the importance of applying electro-osmosis and how doctors can benefit from it during surgeries through proper use.

The purpose of this paper is to numerically study blood flow through a subject‐specific carotid artery with a moderately severe stenosis, also to thoroughly analyse the wall shear stress (WSS), oscillatory shear index (OSI) and WSS angular deviation (WSSAD). One of the important aspects of this study is the investigation on the influence of the extensions attached to the domain outlets.

The segmentation of the carotid artery is carried out using a deformable model based on a level set method. A geometric potential force (GPF) is employed to deform the level set to obtain the carotid artery geometry. The initial surface meshing is generated using an advanced marching cubes (MC) method, before improving the quality of the surface mesh via a number of mesh cosmetic steps. The volume mesh generation has two parts. In the first part, a quasi‐structured, boundary layer mesh is generated in the vicinity of the geometry walls. The second part of the meshing involves unstructured tetrahedral meshing of the inner part of the geometry. After the meshing stage, the flow boundary conditions are generated by numerically solving the Helmholtz equation in both space and time. Finally, the explicit characteristic‐based split (CBS) method is employed in a parallel environment to produce a detailed analysis of wall quantities.

In general, WSS is very high in the vicinity of the carotid artery apex and in the proximity of the stenosis. From the results obtained, it is clear that the influence of outlet domain extension is marginal. While the peak instantaneous WSS differs by a maximum of 5.7 per cent, the time‐averaged WSS difference due to extended domain is only 1.3 per cent. Two other derived parameters are also examined in the paper, the oscillating shear index and the WSSAD. Both these quantities also display minor or negligible differences due to domain extension.

It has been perceived that domain extension is essential to avoid wrong application of boundary conditions. The results obtained, however, conclusively show that the outlet domain extension has only a moderate influence on WSS. Thus, outlet extension to the domains may not be essential for arterial blood flows. It is also observed that the dramatic values of peak WSS obtained near the stenosis is the result of high resolution mesh along with boundary layers used in this study. Both the outcomes represent the originality of this paper.

The purpose of this study is to investigate the monodisperse cavitation of bubbly mixture flow for water and hydrogen mixture flows through a nozzle having a stenosis on the wall.

Two flow regions, namely, quasi-statically stable and quasi-statically unstable increase in the bubble radius, are considered. Different oscillating periods of bubbles in downstream corresponding to various values of Reynolds number are taken into account. The Range–Kutta method is used to tackle nonlinear coupled system of governing equations.

It is observed that for the larger values of Reynolds number, the void fraction at the upstream section, even at small values, yields instabilities at the downstream. Consequently, owing to sudden increase in the velocity, the bubbles strike the wall with high speed that eventually remove the existing stenosis. This process can be considered as an effective cardiac surgery for arteries with semi-blockage.

Original research work and to the best of author’s knowledge, this model is reported for the first time.

Atherosclerosis tends to occur in the distinctive carotid sinus, leading to vascular stenosis and then causing death. The purpose of this paper is to investigate the effect of sinus sizes, positions and hematocrit on blood flow dynamics and heat transfer by different numerical approaches.

The fluid flow and heat transfer in the carotid artery with three different sinus sizes, three different sinus locations and four different hematocrits are studied by both computational fluid dynamics (CFD) and fluid-structure interaction (FSI) methods. An ideal geometric model and temperature-dependent non-Newtonian viscosity are adopted, while the wall heat flux concerning convection, radiation and evaporation is used.

With increasing sinus size, the average velocity and temperature of the blood fluid decrease, and the area of time average wall shear stress (TAWSS)with small values decreases. As the distances between sinuses and bifurcation points increase, the average temperature and the maximum TAWSS decrease. Atherosclerosis is more likely to develop when the sinuses are enlarged, when the sinuses are far from bifurcation points, or when the hematocrit is relatively large or small. The probability of thrombosis forming and developing becomes larger when the sinus becomes larger and the hematocrit is small enough. The movement of the arterial wall obviously reduces the velocity of blood flow, blood temperature and WSS. This study also suggests that the elastic role of arterial walls cannot be ignored.

The hemodynamics of the internal carotid artery sinus in a carotid artery with a bifurcation structure have been investigated thoroughly, on which the impacts of many factors have been considered, including the non-Newtonian behavior of blood and empirical boundary conditions. The results when the FSI is considered and absent are compared.

This bibliography is offered as a practical guide to published papers, conference proceedings papers and theses/dissertations on the finite element (FE) and boundary element (BE) applications in different fields of biomechanics between 1976 and 1991. The aim of this paper is to help the users of FE and BE techniques to get better value from a large collection of papers on the subjects. Categories in biomechanics included in this survey are: orthopaedic mechanics, dental mechanics, cardiovascular mechanics, soft tissue mechanics, biological flow, impact injury, and other fields of applications. More than 900 references are listed.

The effects of steady fluid flow through double bell‐shaped constrictions in tubes were investigated numerically for the Reynolds number range of 5 to 400. The double constrictions studied were for similar first and second constrictions of 1/3, 1/2 and 2/3. A dimensionless constriction spacing of 1.0 was considered. Study showed that the major part of the mean dimensionless pressure drop in the constricted tube occurs predominantly across the first constriction when flow moves towards the valley region formed by the two constrictions. Minimum pressures along the constricted tubes occurs downstream of each constrictions. When the constriction magnitudes increased, the pressure drop across the same length of the tube increases exponentially. The effect of increasing the Reynolds number for all the constriction values considered here is to increase the spreading of the recirculation region between the valley region of the constrictions. The recirculation region formed between the two constrictions has a deminishing effect on the generation of wall vorticity near the second constriction. The effects are more pronounce when the recirculatory flow from the first constriction has spread over the second constriction. In general, a peak wall vorticity is found slightly upstream of each of the constrictions. When the Reynolds number is increased, the peak wall vorticity increases and its location moved upstream. It is noted for the cases considered here that the peak wall vorticity generated by the first constriction is always greater than the peak wall vorticity generated by the second constriction.

This study aims to evaluate the effects of betanin on AMP-activated protein kinase (AMPK), Sirtuin1 (SIRT1) and Sirtuin6 (SIRT6) gene expression as well as the tumour necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) cytokine release in peripheral blood mononuclear cells (PBMCs) of patients with coronary artery disease (CAD) and healthy controls.

PBMCs isolated from whole blood of 50 patients with CAD and 48 healthy subjects aged 45 to 60 years were treated with 10 and 20 µM of betanin for 24 h. Real-time polymerase chain reaction was performed to assess gene expression levels of AMPK, SIRT1 and SIRT6. The supernatants of the cultured cells were used to assess the IL-6 and TNF-α protein levels by ELISA.

Treatment with both doses of betanin significantly increased AMPK, SIRT1 and SIRT6 expression in PBMCs of CAD patients compared to control non-treated cells (p < 0.05). In PBMCs of healthy subjects, only treatment with high dose of betanin showed significant increase in AMPK (p = 0.007), SIRT1 (p = 0.013) and SIRT6 (p = 0.024) expression compared to control non-treated cells. Betanin (20 µM) also significantly decreased TNF-α and IL-6 concentrations in the culture supernatants of the CAD patients compared to control non-treated cells (p < 0.001).

Betanin could enhance AMPK, SIRT1 and SIRT6 gene expressions in PBMCs and represent a useful complementary treatment to reduce the proinflammatory status accompanied with CAD.

Procedures can be categorized as certain surgeries based on their necessity and outcomes while others are classified as uncertain surgeries based on these areas. To account for this variance, policies such as the Affordable Care Act (ACA) call for health care providers to engage in shared decision making (SDM) with patients to ensure they are informed of treatment options and asked their preferences. Yet, gender may influence the decision-making process. Thus, this project examines the decision process and how gender impacts patients’ participation in decisions to undergo certain surgeries compared to uncertain surgeries.

This research project analyzed data from the National Survey of Medical Decisions 2006–2007 which surveyed the medical decisions of US residents 40 and older.

First, the data reveals that women felt more informed having uncertain surgeries compared to men. Second, patients were less likely asked their preference for surgery when undergoing certain surgeries compared to uncertain surgeries. Third, compared to men, women having uncertain surgeries were less likely to make the final decision to have surgery, compared to sharing the final decision with health care providers.

Due to the sample size, this project could not perform three-way interactions between gender, race, and surgery type.

Gender influences the level patients feel informed having uncertain surgeries. Though policy calls for SDM, health care providers are less likely to ask patients their preference for surgery regarding certain surgeries, relative to uncertain surgeries. Gender impacts the final decision-making process regarding whether patients should have uncertain surgeries.

The purpose of this paper is to numerically model forced convection heat transfer within a patient‐specific carotid bifurcation and to examine the relationship between the temperature and wall shear stress.

The procedure employs a parallel, fully explicit (matrix free) characteristic based split scheme for the solution of incompressible Navier‐Stokes equations.

The arterial wall temperature, rather than the blood temperature dominates the regions of low wall shear stress and high oscillating shear stress. Additionally, negligible temperature gradient was detected proximal to the arterial wall in this locality.

The presented results demonstrate a possible mechanism for cold air temperature to influence the atherosclerotic plaque region proximal to the stenosis. The proposed patient‐specific heat transfer analysis also provides a starting point for the investigation of the influence of induced hypothermia on carotid plaque and its stability.