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The focus of this chapter is to describe the methods and results of ASCEND, an innovative program that empowers undergraduate students to lead research projects. ASCEND, which stands for “A Student-Centered Entrepreneurship Development Training Model to Increase Diversity in the Biomedical Research Workforce,” is funded by the National Institutes of Health and is being implemented at Morgan State University, a historically black university in Baltimore, Maryland. The results are thus far very promising and show that placing undergraduate students in leading research positions and surrounding them with like-minded peers enhances their sense of science identity, leadership, peer support, and research capabilities. It is hoped that students who participate in ASCEND will pursue graduate training and become future successful biomedical researchers.