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Computer vision for automated analysis of cells and tissues usually include extracting features from images before analyzing such features via various machine learning and machine vision algorithms. The purpose of this work is to explore and demonstrate the ability of a Convolutional Neural Network (CNN) to classify cells pictured via brightfield microscopy without the need of any feature extraction, using a minimum of images, improving work-flows that involve cancer cell identification.

The methodology involved a quantitative measure of the performance of a Convolutional Neural Network in distinguishing between two cancer lines. In their approach, they trained, validated and tested their 6-layer CNN on 1,241 images of MDA-MB-468 and MCF7 breast cancer cell line in an end-to-end fashion, allowing the system to distinguish between the two different cancer cell types.

They obtained a 99% accuracy, providing a foundation for more comprehensive systems.

Value can be found in that systems based on this design can be used to assist cell identification in a variety of contexts, whereas a practical implication can be found that these systems can be deployed to assist biomedical workflows quickly and at low cost. In conclusion, this system demonstrates the potentials of end-to-end learning systems for faster and more accurate automated cell analysis.

In the developing field of nano-materials synthesis, copper oxide nanoparticles (NPs) are deemed to be one of the most significant transition metal oxides because of their intriguing characteristics. Its synthesis employing green chemistry principles has become a key source for next-generation antibiotics attributed to its features such as environmental friendliness, ease of use and affordability. Because they are more environmentally benign, plants have been employed to create metallic NPs. These plant extracts serve as capping, stabilising or hydrolytic agents and enable a regulated synthesis as well.

Organic chemical solvents are harmful and entail intense conditions during nanoparticle synthesis. The copper oxide NPs (CuO-NPs) synthesised by employing the green chemistry principle showed potential antitumor properties. Green synthesised CuO-NPs are regarded to be a strong contender for applications in the pharmacological, biomedical and environmental fields.

The aim of this study is to evaluate the anticancer potential of CuO-NPs plant extracts to isolate and characterise the active anticancer principles as well as to yield more effective, affordable, and safer cancer therapies.

This review article highlights the copper oxide nanoparticle's biomedical applications such as anticancer, antimicrobial, dental and drug delivery properties, future research perspectives and direction are also discussed.

This work presents a system based on an ensemble of Convolutional Neural Networks (CNNs) and descriptors for bioimage classification that has been validated on different datasets of color images. The proposed system represents a very simple yet effective way of boosting the performance of trained CNNs by composing multiple CNNs into an ensemble and combining scores by sum rule. Several types of ensembles are considered, with different CNN topologies along with different learning parameter sets. The proposed system not only exhibits strong discriminative power but also generalizes well over multiple datasets thanks to the combination of multiple descriptors based on different feature types, both learned and handcrafted. Separate classifiers are trained for each descriptor, and the entire set of classifiers is combined by sum rule. Results show that the proposed system obtains state-of-the-art performance across four different bioimage and medical datasets. The MATLAB code of the descriptors will be available at https://github.com/LorisNanni.

The article applies the citizen science phenomenon – i.e. lay people involvement in research endeavours aimed at pushing forward scientific knowledge – to healthcare. Attention is paid to initiatives intended to tackle the COVID-19 pandemic as an illustrative case to exemplify the contribution of citizen science to system-wide innovation in healthcare.

A mixed methodology consisting of three sequential steps was developed. Firstly, a realist literature review was carried out to contextualize citizen science to healthcare. Then, an account of successfully completed large-scale, online citizen science projects dealing with healthcare and medicine has been conducted in order to obtain preliminary information about distinguishing features of citizen science in healthcare. Thirdly, a broad search of citizen science initiatives targeted to tackling the COVID-19 pandemic has been performed. A comparative case study approach has been undertaken to examine the attributes of such projects and to unravel their peculiarities.

Citizen science enacts the development of a lively healthcare ecosystem, which takes its nourishment from the voluntary contribution of lay people. Citizen scientists play different roles in accomplishing citizen science initiatives, ranging from data collectors to data analysts. Alongside enabling big data management, citizen science contributes to lay people's education and empowerment, soliciting their active involvement in service co-production and value co-creation.

Citizen science is still underexplored in healthcare. Even though further evidence is needed to emphasize the value of lay people's involvement in scientific research applied to healthcare, citizen science is expected to revolutionize the way innovation is pursued and achieved in the healthcare ecosystem. Engaging lay people in a co-creating partnership with expert scientist can help us to address unprecedented health-related challenges and to shape the future of healthcare. Tailored health policy and management interventions are required to empower lay people and to stimulate their active engagement in value co-creation.

Citizen science relies on the wisdom of the crowd to address major issues faced by healthcare organizations. The article comes up with a state of the art investigation of citizen science in healthcare, shedding light on its attributes and envisioning avenues for further development.

The establishment of partnerships between companies, government and universities aims to enhance innovation and the technological development of institutions. The biotechnology sector has grown in recent years mainly driven by its cooperative business model. Compared to other countries, this sector is slowly advancing in Brazil, with delays in science, technology and innovation, especially in the private sector. This paper aims to examine, through social network analysis, the collaborative networks between institutions that filed patents in biotechnology – medicinal preparations from plants – whose inventions had Brazil as the priority country.

The study of technological cooperation using patent documents is a reliable approach as they serve as good indicators of the interactions between organizations that focus on innovation and development of new product. Social network analysis of cooperation networks helps to understand the connections between patent assignees, and how they establish relationships.

Results show that public universities are the institutions that most deposit patents, as well as those that co-operate the most, especially Universidade of Campinas. The study also reveals the critical role of Research Support Agencies in stimulating research and technological development, which result in new technologies.

The study applied the social network analysis to provide an overview of the interactions among Brazilian institutions with the purpose of helping in decision-making and inciting public policies to leverage the biotechnology sector.

The goal of this research is to analyse the obstacles to the implementation of mobile health (mHealth) in India and to gain an understanding of the contextual inter-relationships that exist amongst those obstacles.

Potential barriers and their interrelationships in their respective contexts have been uncovered. Using MICMAC analysis, the categorization of these barriers was done based on their degree of reliance and driving power (DP). Furthermore, an interpretive structural modeling (ISM) framework for the barriers to mHealth activities in India has been proposed.

The study explores a total of 15 factors that reduce the efficiency of mHealth adoption in India. The findings of the Matrix Cross-Reference Multiplication Applied to a Classification (MICMAC) investigation show that the economic situation of the government, concerns regarding the safety of intellectual technologies and privacy issues are the primary obstacles because of the significant driving power they have in mHealth applications.

Promoters of mHealth practices may be able to make better plans if they understand the social barriers and how they affect each other; this leads to easier adoption of these practices. The findings of this study might be helpful for governments of developing nations to produce standards relating to the deployment of mHealth; this will increase the efficiency with which it is adopted.

At this time, there is no comprehensive analysis of the factors that influence the adoption of mobile health care with social cognitive theory in developing nations like India. In addition, there is a lack of research in investigating how each of these elements affects the success of mHealth activities and how the others interact with them. Because developed nations learnt the value of mHealth practices during the recent pandemic, this study, by investigating the obstacles to the adoption of mHealth and their inter-relationships, makes an important addition to both theory and practice.

Many entrepreneurs are able to manage their businesses within relatively contained and familiar geographical and cultural circles. With a world economy shrinking every day amid a flood of digital information, todayʼs entrepreneur is increasingly confronted with opportunities to consider new ways to secure vendors and recruit customers. Many unfamiliar possibilities emerge. Should the entrepreneur venture beyond “comfortable” surroundings to consider international connections? Specifically, what about China? How practical is this fetching business temptation of larger markets and lower-cost subcontractors? What are the social, trade, financial, and political issues? Should a “China strategy” be a true entrepreneurial offensive, or rather a defensive response to competition? Is this “China strategy” the promise of yet another entrepreneurial nirvana? Or is it perhaps again a case of “Be careful of what you wish for; it may really come true?”

The purpose of this study is to develop a model for automated classification of old digitised texts to the Universal Decimal Classification (UDC), using machine-learning methods.

The general research approach is inherent to design science research, in which the problem of UDC assignment of the old, digitised texts is addressed by developing a machine-learning classification model. A corpus of 70,000 scholarly texts, fully bibliographically processed by librarians, was used to train and test the model, which was used for classification of old texts on a corpus of 200,000 items. Human experts evaluated the performance of the model.

Results suggest that machine-learning models can correctly assign the UDC at some level for almost any scholarly text. Furthermore, the model can be recommended for the UDC assignment of older texts. Ten librarians corroborated this on 150 randomly selected texts.

The main limitations of this study were unavailability of labelled older texts and the limited availability of librarians.

The classification model can provide a recommendation to the librarians during their classification work; furthermore, it can be implemented as an add-on to full-text search in the library databases.

The proposed methodology supports librarians by recommending UDC classifiers, thus saving time in their daily work. By automatically classifying older texts, digital libraries can provide a better user experience by enabling structured searches. These contribute to making knowledge more widely available and useable.

These findings contribute to the field of automated classification of bibliographical information with the usage of full texts, especially in cases in which the texts are old, unstructured and in which archaic language and vocabulary are used.

This paper aims to assess the consumption of dairy products in Kuwaiti children, and develop and validate a semi-quantitative food frequency questionnaire to measure dairy product consumption.

This cross-sectional study was based on a sample of child–parent dyads (n = 150). A dietary assessment questionnaire on local dairy products consumed by preschool and preadolescent children was developed. Serving and portion sizes were evaluated on the basis of the guidelines of the United States Department of Agriculture and the American Academy of Pediatrics to calculate median intake levels of three age groups (3-5, 6-8 and 9-11 years).

All children met or exceeded the recommended daily servings of dairy products for their age and sex. Dairy product intake was often from processed dairy including milk-based desserts, flavored milk and cheese. Compared to boys, girls consumed more yogurt (15.5 per cent vs 14.2 per cent, p = 0.001) and milk-based desserts (15.5 vs 14.3, p = 0.001). In boys, flavored milk contributed more to the total dairy intake than in girls, especially in 6-8-year-olds (21.8 per cent vs 18.9 per cent, p = 0.021). Weight status was not associated with dairy product intake in either sex.

This is the first study that quantifies dairy product consumption in Kuwaiti children and provides insight into sex-specific trends in dairy product selection. The findings of this study may help in investigating relationships between dairy product consumption in children and disease risk factors, and are important for the development of local dietary guidelines for children.

Diagnosing brain tumors is a process that demands a significant amount of time and is heavily dependent on the proficiency and accumulated knowledge of radiologists. Over the traditional methods, deep learning approaches have gained popularity in automating the diagnosis of brain tumors, offering the potential for more accurate and efficient results. Notably, attention-based models have emerged as an advanced, dynamically refining and amplifying model feature to further elevate diagnostic capabilities. However, the specific impact of using channel, spatial or combined attention methods of the convolutional block attention module (CBAM) for brain tumor classification has not been fully investigated.

To selectively emphasize relevant features while suppressing noise, ResNet50 coupled with the CBAM (ResNet50-CBAM) was used for the classification of brain tumors in this research.

The ResNet50-CBAM outperformed existing deep learning classification methods like convolutional neural network (CNN), ResNet-CBAM achieved a superior performance of 99.43%, 99.01%, 98.7% and 99.25% in accuracy, recall, precision and AUC, respectively, when compared to the existing classification methods using the same dataset.

Since ResNet-CBAM fusion can capture the spatial context while enhancing feature representation, it can be integrated into the brain classification software platforms for physicians toward enhanced clinical decision-making and improved brain tumor classification.

This research has not been published anywhere else.