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Book part
Publication date: 21 November 2022

Roger D. Masters

Research at the intersection of neurotoxicology, cognitive neuroscience, genetics, and behavior – “toxicogenomics” – promises to improve understanding of behavior and public…

Abstract

Research at the intersection of neurotoxicology, cognitive neuroscience, genetics, and behavior – “toxicogenomics” – promises to improve understanding of behavior and public policies. Many toxicants modify neurotransmitters with effects depending on genotype, development, and experience. For example, lead and manganese downregulate dopaminergic or serotonergic function, weaken behavioral inhibition, and are positively correlated with hyperactivity (ADHD), substance abuse, or violent crime. Within this context, the chapter argues that neurotoxicology holds great promise for improving public policies in areas such as criminal justice and education. After discussing research methods, the chapter surveys previous work in neurotoxicology as it pertains to educational outcomes and to crime. Data are summarized linking: (1) children's blood lead levels with poor educational performance; (2) hair and blood levels of heavy metals with violent crime; and (3) uptake of multiple toxicants with pollution from abandoned mines. The chapter concludes by drawing lessons for ongoing research agendas at the intersection of neurotoxins, behavior, and policy.

Details

Biopolitics at 50 Years
Type: Book
ISBN: 978-1-80262-108-2

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Book part
Publication date: 14 June 2012

Roger D. Masters

Purpose – Description of the effects of the revolution in neuroscience and other areas of biology that can help to explain the roots of some portion of violent crime. The chapter…

Abstract

Purpose – Description of the effects of the revolution in neuroscience and other areas of biology that can help to explain the roots of some portion of violent crime. The chapter reconsiders the role of brain chemistry in social behavior and violent behavior. To illustrate the interdisciplinary complexities entailed when linking brain chemistry to policy decisions concerning violent crime, this analysis has four main stages: first, why might SiFs (H2SiF6 and Na2SiF6, jointly called “silicofluorides” or SiFs) be dangerous? Second, what biochemical effects of SiF could have toxic consequences for humans? Third, on this basis a research hypothesis predicts children in communities using SiF should have increased uptake of lead from environmental sources and higher rates of behavioral dysfunctions known to be caused by lead neurotoxicity.

Design/methodology/approach – To illustrate the implications of the new issues involved, this chapter focuses on a public policy that inadvertently seems to increase rates of violent crime. Since violent behavior is one of the effects of lead neurotoxicity, the hypothesis is tested using multiple sources of data including rates of violent crime studied using a variety of multivariate statistical techniques (including analysis of variance, multiple regression, and stepwise regression).

Findings – Various data sources point to greater violence among individuals with greater exposure to SiFs.

Originality/value – Testing hypotheses linking neurotoxins to violent behavior reveals the generally unsuspected value of analyzing human social behavior and public policy from the perspective of evolutionary psychology.

Details

Biopolicy: The Life Sciences and Public Policy
Type: Book
ISBN: 978-1-78052-821-2

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Article
Publication date: 24 May 2011

Eman A.E. Badr, Asmaa A.E. Agrama and Safaa A.E. Badr

This study seeks to find out if chronic exposure via drinking water to high doses of a mixture of metals found as contaminants in tap and bottled water sources can alter the…

1701

Abstract

Purpose

This study seeks to find out if chronic exposure via drinking water to high doses of a mixture of metals found as contaminants in tap and bottled water sources can alter the systemic physiology of residents.

Design/methodology/approach

A case control study was designed, 18 subjects drinking mainly tap water as main group (group I) and 15 subjects drinking exclusively bottled water as control group (group II) for a minimum of two years. Cadmium, lead, chromium and iron concentrations in drinking tap and bottled water samples were measured. The effect potential of the same metals were evaluated by assessing liver and kidney functions and haemoglobin levels for the studied subjects.

Findings

Iron concentration was found to be significantly higher in drinking tap water samples compared to bottled. Chromium, lead and iron were significantly higher in blood samples of group I subjects compared to the control group. Blood creatinine levels were positively correlated with that of chromium and cadmium of group I; and chromium levels of group II. Urea levels was positively correlated with lead levels of group I. Haemoglobin was positively correlated with iron blood levels of group I and negatively with lead levels of group II. No appreciable changes were found in the blood clinical markers of the liver functions of either group.

Originality/value

This study gives a concise idea about the higher level of some heavy metals in tap water compared to bottled and how heavy metal contaminants in drinking water may affect kidney function and haemoglobin level of consumers.

Details

Nutrition & Food Science, vol. 41 no. 3
Type: Research Article
ISSN: 0034-6659

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Article
Publication date: 1 June 1994

Barry S. Kendler

Aims to: familiarize the audience with the potentially seriousconsequences of exposure to lead and ways of preventing them; facilitateunderstanding of how massive environmental…

957

Abstract

Aims to: familiarize the audience with the potentially serious consequences of exposure to lead and ways of preventing them; facilitate understanding of how massive environmental contamination with lead occurred, and is still happening, with the expectation that this knowledge will be useful in designing strategies to reduce environmental contamination with lead and other toxic substances, in the future; emphasizes the relevance of lead to the subject‐matter of virtually every department in schools of arts and sciences in anticipation that some instructors will incorporate this information into their respective courses to increase their students′ awareness of this topic. Discusses some of the properties and uses of lead and its compounds and then indicates its ubiquitous presence in air, water, soil, dust and food. Considers some effects of exposure to lead and describes some pivotal contributions of various researchers. Explores the role of lead in history, in literature and in art. Briefly surveys occupational exposure to lead in the USA and elsewhere. Describes the reasons for, and consequences of, lead in petrol and in paint. Summarizes an outstanding paper on the topic of values and lead. Finally, based on an examination of a portion of the voluminous literature on lead, offers some opinions on this subject.

Details

Structural Survey, vol. 12 no. 3
Type: Research Article
ISSN: 0263-080X

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Article
Publication date: 1 October 2001

Z. Hashisho and M. El‐Fadel

Lead emissions from vehicles using leaded gasoline is a serious environmental problem in urban areas. While leaded gasoline has been completely phased out in many developed…

Abstract

Lead emissions from vehicles using leaded gasoline is a serious environmental problem in urban areas. While leaded gasoline has been completely phased out in many developed countries, it is still the predominant fuel grade in most developing countries. This paper presents an estimation of the health and economic benefits and costs of the transition from leaded to unleaded gasoline in Lebanon based on relevant dose‐response functions and available country‐specific data. Comparing the potential costs of the phase‐out and the predicted benefits, it was concluded that such action is economically highly justified.

Details

Environmental Management and Health, vol. 12 no. 4
Type: Research Article
ISSN: 0956-6163

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Book part
Publication date: 1 October 2013

Manuel Vallée

Since the beginning of the 20th century environmental health researchers have known about the association between toxicant exposure and disease. However, that knoweldge has not…

Abstract

Purpose

Since the beginning of the 20th century environmental health researchers have known about the association between toxicant exposure and disease. However, that knoweldge has not been well integrated into mainstream medicine. Shedding light on why is the focus of this chapter.

Methodology/approach

To shed light on this issue I analyze the 2011 American Academy of Pediatrics’ clinical practice guidelines for Attention Deficit/Hyperactivity Disorder (ADHD), focusing specifically on the omission of environmental health research pertaining to ADHD symptoms and exposures, such as lead and mercury.

Findings

I found that while environmental researchers have been documenting the link between lead and ADHD for over forty years, the American Academy of Pediatrics has completely omitted this research from its 2012 clinical practice guidelines. Moreover, I argue this omission can be traced to competitive pressures to protect medical jurisdiction, and a reductionist worldview that emphasizes treatment over prevention.

Originality/value of paper

This is the first attempt to analyze the way clinical practice guidelines help reinforce and perpetuate dominant medical perspectives. Moreover, to shed explanatory light, this chapter offers a synthetic explanation that combines materialist and ideological factors.

Research implications

Beyond the specific case of ADHD, this chapter has implications for understanding how and why environmental health research is omitted from other materials produced by mainstream medicine, such as materials found in the medical school curriculum, continuing medical education, medical journals, and on the medical association web sites.

Article
Publication date: 1 January 1973

The new authorities created by this Act, probably the most important local government measure of the century, will be voted into existence during 1973 and commence functioning on…

Abstract

The new authorities created by this Act, probably the most important local government measure of the century, will be voted into existence during 1973 and commence functioning on 1st April 1974. Their responsibilities and the problems facing them are in many ways quite different and of greater complexity than those with which existing councils have had to cope. In its passage through the Lords, a number of amendments were made to the Act, but in the main, it is a scheme of reorganization originally produced after years of discussion and long sessions in the Commons. Local government reorganization in Scotland takes place one year later and for Northern Ireland, we must continue to wait and pray for a return of sanity.

Details

British Food Journal, vol. 75 no. 1
Type: Research Article
ISSN: 0007-070X

Content available
Article
Publication date: 1 June 2001

31

Abstract

Details

Nutrition & Food Science, vol. 31 no. 3
Type: Research Article
ISSN: 0034-6659

Article
Publication date: 1 February 1998

Barbara A. Haley

Discusses prevention of lead poisoning among US children, claiming that it is entirely preventable yet is the most common environmentally induced disease in children. Outlines the…

Abstract

Discusses prevention of lead poisoning among US children, claiming that it is entirely preventable yet is the most common environmentally induced disease in children. Outlines the extent of the problem then focuses on legislation, what the various acts were meant to achieve, and how they can be enforced. Explains how sociological skills were used in the author’s work for the US Department of Housing and Urban Development. Indicates that sociologists can help in a number of fields not immediately linked to sociology.

Details

International Journal of Sociology and Social Policy, vol. 18 no. 1
Type: Research Article
ISSN: 0144-333X

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Article
Publication date: 1 April 1994

Michael J. Osborn

Draws attention to the poisonous effects of lead and details thelegislation which protects those who work in industries which use leadin their processes and manufactures. Gives…

330

Abstract

Draws attention to the poisonous effects of lead and details the legislation which protects those who work in industries which use lead in their processes and manufactures. Gives particular consideration to lead in paint, especially to be found in houses built pre‐1965, and the inherent dangers in the removal of such paint to contractors, DIY enthusiasts and the occupants, especially children, who are more susceptible to lead absorption. Provides details of preventive measures, and concludes that surveyors have a responsibility to warn of the dangers of lead in property and to test for its presence in paint and water supplies.

Details

Structural Survey, vol. 12 no. 2
Type: Research Article
ISSN: 0263-080X

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