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The healthcare sector faces severe problems due to increasing costs, decreasing workforce and an increasing share of elderly people. Innovation is proposed as the main cure. However, there are several barriers that prevent new ideas from becoming innovations. In this chapter we focus on the biomedical engineering sector and the barriers to commercialisation that are present for applied research projects within this sector. We describe and categorise the barriers and discuss their implications and how they could be overcome. This study has a longitudinal approach and is based on data collected annually through half-structured interviews for approximately 40 research and development projects at four universities, two hospitals and one municipality healthcare centre, across eastern and central Sweden. Our results found a broad range of barriers to commercialisation, which have been categorised as follows: (1) Barriers coupled to the healthcare sector per se, for example security regulations, procedures for governmental procurement and the industry structure. (2) Barriers related to the market structure, for example public procurement matters and the fact that hospitals commonly look for holistic solutions rather than pieces and gadgets that solve isolated parts of problems. (3) Barriers related to entrepreneurship attitudes among researchers. The findings contribute to research on the ability to create innovation in a highly prioritised sector.

Illustrates a case story detailing the customer‐vendor co‐operation in a project concerning the beta test of hardware and software at a radiology department. A qualitative analysis of the project has unveiled that contextual conditions like the nature of the technology, the organizational structure at both the customer and the vendor side, the development strategy, and the project organization were very important forces during the project. Technologically, the project was more complex than usually was seen at the hospital because it concerned both biomedical and administrative aspects. Conflicting interests in particular on the part of the customer side as well as between the customer and the vendor affected the course of the project. Methodologically, the project lacked a proper strategy for the co‐operative process. There was no formalized project organization which otherwise could have provided different conditions for the project.

In the past decade, three-dimensional (3D) printing has gained attention in areas such as medicine, engineering, manufacturing art and most recently in education. In biomedical, the development of a wide range of biomaterials has catalysed the considerable role of 3D printing (3DP), where it functions as synthetic frameworks in the form of scaffolds, constructs or matrices. The purpose of this paper is to present the state-of-the-art literature coverage of 3DP applications in tissue engineering (such as customized scaffoldings and organs, and regenerative medicine).

This review focusses on various 3DP techniques and biomaterials for tissue engineering (TE) applications. The literature reviewed in the manuscript has been collected from various journal search engines including Google Scholar, Research Gate, Academia, PubMed, Scopus, EMBASE, Cochrane Library and Web of Science. The keywords that have been selected for the searches were 3 D printing, tissue engineering, scaffoldings, organs, regenerative medicine, biomaterials, standards, applications and future directions. Further, the sub-classifications of the keyword, wherever possible, have been used as sectioned/sub-sectioned in the manuscript.

3DP techniques have many applications in biomedical and TE (B-TE), as covered in the literature. Customized structures for B-TE applications are easy and cost-effective to manufacture through 3DP, whereas on many occasions, conventional technologies generally become incompatible. For this, this new class of manufacturing must be explored to further capabilities for many potential applications.

This review paper presents a comprehensive study of the various types of 3DP technologies in the light of their possible B-TE application as well as provides a future roadmap.

The main objective of this paper is to illustrate an analytical view of different methods of 3D bioprinting, variations, formulations and characteristics of biomaterials. This review also aims to discover all the areas of applications and scopes of further improvement of 3D bioprinters in this era of the Fourth Industrial Revolution.

This paper reviewed a number of papers that carried evaluations of different 3D bioprinting methods with different biomaterials, using different pumps to print 3D scaffolds, living cells, tissue and organs. All the papers and articles are collected from different journals and conference papers from 2014 to 2022.

This paper briefly explains how the concept of a 3D bioprinter was developed from a 3D printer and how it affects the biomedical field and helps to recover the lack of organ donors. It also gives a clear explanation of three basic processes and different strategies of these processes and the criteria of biomaterial selection. This paper gives insights into how 3D bioprinters can be assisted with machine learning to increase their scope of application.

The chosen research approach may limit the generalizability of the research findings. As a result, researchers are encouraged to test the proposed hypotheses further.

This paper includes implications for developing 3D bioprinters, developing biomaterials and increasing the printability of 3D bioprinters.

This paper addresses an identified need by investigating how to enable 3D bioprinting performance.

The potential implications of the three-dimensional printing (3DP) technology are growing enormously in the various health-care sectors, including surgical planning, manufacturing of patient-specific implants and developing anatomical models. Although a wide range of thermoplastic polymers are available as 3DP feedstock, yet obtaining biocompatible and structurally integrated biomedical devices is still challenging owing to various technical issues.

Polyether ether ketone (PEEK) is an organic and biocompatible compound material that is recently being used to fabricate complex design geometries and patient-specific implants through 3DP. However, the thermal and rheological features of PEEK make it difficult to process through the 3DP technologies, for instance, fused filament fabrication. The present review paper presents a state-of-the-art literature review of the 3DP of PEEK for potential biomedical applications. In particular, a special emphasis has been given on the existing technical hurdles and possible technological and processing solutions for improving the printability of PEEK.

The reviewed literature highlighted that there exist numerous scientific and technical means which can be adopted for improving the quality features of the 3D-printed PEEK-based biomedical structures. The discussed technological innovations will help the 3DP system to enhance the layer adhesion strength, structural stability, as well as enable the printing of high-performance thermoplastics.

The content of the present manuscript will motivate young scholars and senior scientists to work in exploring high-performance thermoplastics for 3DP applications.

This study aims to investigate a critical review on the applications of fluid-structure interaction (FSI) in porous media.

Transport phenomena in porous media are of continuing interest by many researchers in the literature because of its significant applications in engineering and biomedical sectors. Such applications include thermal management of high heat flux electronic devices, heat exchangers, thermal insulation in buildings, oil recovery, transport in biological tissues and tissue engineering. FSI is becoming an important tool in the design process to fully understand the interaction between fluids and structures.

This study is structured in three sections: the first part summarizes some important studies on the applications of porous medium and FSI in various engineering and biomedical applications. The second part focuses on the applications of FSI in porous media as related to hyperthermia. The third part of this review is allocated to the applications of FSI of convection flow and heat transfer in engineering systems filled with porous medium.

To the best knowledge of the present authors, FSI analysis of turbulent flow in porous medium never been studied, and therefore, more attention should be given to this area in any future studies. Moreover, more studies should also be conducted on mixed convective flow and heat transfer in systems using porous medium and FSI.

The wall of the blood vessel is considered as a flexible multilayer porous medium, and therefore, rigid wall analysis is not accurate, and therefore, FSI should be implemented for accurate predictions of flow and hemodynamic stresses.

The use of porous media theory in biomedical applications received a great attention by many investigators in the literature (Khanafer and Vafai, 2006a; Al-Amiri et al., 2014; Lasiello et al., 2016a, Lasiello et al., 2016b; Lasiello et al., 2015; Chung and Vafai, 2013; Mahjoob and Vafai, 2009; Yang and Vafai, 2008; Yang and Vafai, 2006; Ai and Vafai, 2006). A comprehensive review was conducted by Khanafer and Vafai (2006b) summarizing various studies associated with magnetic field imaging and drug delivery. The authors illustrated that the tortuosity and porosity had a profound effect on the diffusion process within the brain. AlAmiri et al. (2014) conducted a numerical study to investigate the effect of turbulent pulsatile flow and heating technique on the thermal distribution within the arterial wall. The results of that investigation illustrated that local heat flux variation along the bottom layer of the tumor was greater for the low-velocity condition. Yang and Vafai (2006) presented a comprehensive four-layer model to study low-density lipoprotein transport in the arterial wall coupled with a lumen (Figure 1). All the four layers (endothelium, intima, internal elastic lamina and media) were modeled as a homogenous porous medium.

Future studies on the applications of FSI in porous media are recommended in this review.

There has been a great deal of research published on the lower success rates of women and underrepresented (UR) students in Science, technology, engineering, and mathematics-related (STEM) occupations. For biomedical scientists in particular, many of the obstacles to success occur during graduate training and may be related, at least in part, to certain demographic characteristics (i.e. gender or ethnicity). In particular, women and UR students may be positioned disproportionately into labs with fewer resources and less productive faculty advisors. The paper aims to discuss these issues.

The present study examines the distribution of biomedical science graduate students into research laboratories, based on the gender and ethnicity of both students and faculty advisors. This is archival data that were collected via publicly available information on the internet.

Results indicate that female (vs male) students and UR (vs white and Asian) students are paired with advisors who are less successful (i.e. fewer publications, lower h-indices). Additionally, the data show patterns of homophily in that female (vs male) and white and Asian (vs UR) students are more likely to be paired with female and white and Asian advisors, respectively.

This research uses real-world, archival data to demonstrate that phenomena suggested in previous literature (e.g. less favorable pairings for female and UR students, homophilic pairings) occurs with this specific population.

This paper aims to report a prototype of a reliable method for rapid, sensitive bacterial detection by using a low-cost zinc oxide nanorods (ZnONRs)-based electrochemical sensor.

The ZnONRs have been grown on the surface of a disposable, miniaturized working electrode (WE) using the low-temperature hydrothermal technique. Scanning electron microscopy and energy dispersion spectroscopy have been performed to characterize the distribution as well as the chemical composition of the ZnONRs on the surface, respectively. Moreover, the cyclic voltammetry test has been implemented to assess the effect of the ZnONRs on the signal conductivity between −1 V and 1 V with a scan rate of 0.01 V/s. Likewise, the effect of using different bacterial concentrations in phosphate-buffered saline has been investigated.

The morphological characterization has shown a highly distributed ZnONR on the WE with uneven alignment. Also, the achieved response time was about 12 minutes and the lower limit of detection was approximately 103 CFU abbreviation for Colony Forming Unit/mL.

This paper illustrates an outcome of an experimental work on a ZnONRs-based electrochemical biosensor for direct detection of bacteria.

This paper aims to provide an overview of applications of medical rapid prototyping (MRP)-assisted customized surgical guides (CSGs) and shows the potential of this technology in complex surgeries. This review paper also reports two case studies from open literature where MRP-assisted CSGs have been successfully used in complex surgeries.

Key publications from the past two decades have been reviewed.

This study concludes that the use of MRP-assisted CSGs improves the accuracy of surgery. Additionally, MRP-assisted CSGs make the surgery much faster, accurate and cheaper than any other technique. The outcome based on literature review and two case studies strongly suggested that MRP-assisted CSGs might become part of a standard protocol in the medical sector to operate the various complex surgeries, in the near future.

Advanced technologies like radiology, image processing, virtual surgical planning (VSP), computer-aided design (CAD) and MRP made it possible to fabricate the CSGs. MRP-assisted CSGs can easily transfer the VSP into the actual surgery.

This paper is beneficial to study the development and applications of MRP-assisted CSGs in complex surgeries.

To describe new features and functionality of blogging and share a range of applications in the library environment.

Demonstrates the range of applications and suggests that this is a new information medium that is likely to have a keen presence for a long while as more users engage in the related activities and depend on Blogs and RSS for their sources of information.

Implementations in ways librarians never expected are now becoming common and the role of blogging and the challenges associated with tracking content on blogs remains of great interest. The wide spectrum of information sources and functionality of blogs proves to be ever‐changing.

Provides library community new ideas in how to implement blogs that will serve users in creative, positive and meaningful ways.