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Linear supply chain models often overlook the impact that end-users (i.e. people who “consume” or otherwise realize the intended value of the product or service) can have on core supply chain processes. As the global trade environment rapidly evolves, business and government leaders are seeking more regionalized, sustainable circular models that position “consumers” at the center of dynamic value creation and consumption networks. This chapter outlines some ways to leverage end-users of the value chain to inform development and sustainment of circular supply chain strategies and processes. First, we describe the economic, social, and ecological trends that motivate organizational leaders and managers to implement more circular supply chain models. We then provide specific ideas on how managers can leverage end-users to close, slow, narrow, intensify, and dematerialize core supply chain processes.