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Plant materials continue to play a major role in primary health care as therapeutic remedies in many developing countries. Medicinal herbs contain physiologically active principles that over the years have been exploited in traditional medicine for the treatment of various ailments as they contain antimicrobial properties. This paper aims to determine the antibacterial activity of Iranian endemic plants.

Antibacterial activities of ethanol extract and essential oil of ten Iranian folklore herbs including Heracleum lasiopetalum Boiss., Hypericum scabrum L., Thymus daenensis Celak., Ziziphora teniur L., Echiophora platyloba L., Dracocephalum multicaule Benth., Kelussia odoratissima Mozff., Mentha longifolia Hudson., Achillea kellalensis Boiss. and Arnebia euchroma (Royle.) Johnston. were investigated against Yersinia enterocolitica PTCC 1151 by agar disc diffusion and serial dilution assays.

Most of the extracts and essential oils showed some antibacterial activity against the tested bacteria with the diameter of inhibition zone ranging between 9 and 16 mm. Of the plants studied, the most active extracts were those obtained from essential oil of H. lasiopetalum fruits and ethanol extract of A. euchroma roots. The MIC values for active extract and essential oil ranged between 0.039 and 0.156 mg/ml.

The results obtained appeared to confirm the antibacterial potential of the plants investigated.

The essential oil <0.039 mg/ml of H. lasiopetalum fruits could be used as natural antibacterial agent Y. enterocolitica in the food preservation and human health.