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The purpose of this paper is to focus on economics literature on antimicrobial and alternative uses in food animal production on its current state, its drivers, impacts and policy, and provides a general picture of the research for this special agricultural input and future directions for the research and policy.

Reduction of antimicrobial uses in food animal production is relevant to both preventing antimicrobial resistance and ensuring global food security. This study focuses on reviewing antimicrobial impact on global food security, particularly in farm production by documenting the main drivers, functions and alternatives of antimicrobial animal uses, comparing different approaches used in evaluating its production effects and providing recommendations for future research and policy development.

Three main approaches, controlled animal experiments, comparisons between with and without using antimicrobials at the farm level and comparisons before and after antimicrobial ban as growth promoter, have been used in measuring food security effects of antimicrobial uses in food animal production. They are, however, answering different questions with different measuring conditions. The positive production impact of antimicrobial use is often associated to its functions as a growth promoter and in preventing and treating diseases. In this review the author question the technical legitimacy for antimicrobials as a growth promoter and argue that antimicrobials should be treated as a special class of conditional and supportive input in farm production instead of using it as a normal input in its impact evaluation.

An approach of combining damage control function and disease epidemiological model instead of a simplified production function should be used in its impact evaluation including in evaluating those used as antimicrobial growth promoters.

In reducing antimicrobial uses in animal production, apart from more active adoption of the alternatives, we call for a better understanding for the decision makings of antimicrobial use in the production process including government-veterinarian-farm links.

This study examines the main issues in current economic research in antimicrobial food animal production, clarifies ambiguities in antimicrobial production functions and in different approaches used in impact evaluation, provides a roadmap for reduction of antimicrobial uses and a new approach for the policy evaluation.

The purpose of this paper is to explore the current state of antimicrobial stewardship implementation and development within Canada at both a federal and provincial level.

Narrative review.

There have been several prominent conferences and reports in Canada regarding the development and implementation of antimicrobial stewardship programs over the past two decades. However, despite the knowledge that there is a need for standardization of programs across Canada with accurate mechanisms and infrastructure in place for implementation and evaluation of these programs, there is still a lack of consistency across the country. In addition pharmacy information regarding inpatient and outpatient antimicrobial use is not uniformly reliable. Recently, the Public Health Agency of Canada using the Pan-Canadian Public Health Network as a vehicle organized a task group to help facilitate the working relationships among the provincial, territorial and federal governments in terms of implementing antimicrobial stewardship programs. This network has the potential to enhance and standardize programs across the country.

This paper looks at Canadian policy regarding antimicrobial stewardship at a federal as well as provincial level. Historic conferences, reports and discussions are highlighted emphasizing the progressive changes over the past two decades and highlight many of the challenges that Canada continues to face.

The purpose of this paper is to establish a suitable procedure for producing antimicrobial 100 per cent cotton textiles using zinc pyrithione. Zinc pyrithione being bacteriostatic in nature is eco-friendly and safe, both for manufacturer to apply and consumer to use.

After conducting laboratory trials, bulk trial has also been conducted, and efficacy of zinc pyrithione as bacteriostatic has been quantitatively determined. The durability of antimicrobial finish was also checked before and after repeated domestic laundry.

The findings indicated that it is possible to produce durable antimicrobial 100 per cent cotton textiles in bulk using zinc pyrithione.

Any exporting textile processing mill can directly use the findings of this work and can produce antimicrobial textiles in their factory.

Any exporting textile mill can increase their export earnings by producing antimicrobial textiles. The antimicrobial textiles are in great demand in Asia-Pacific region and have already touched exports of US$497.4m in 2015 and is projected to reach US$1,076.1m by 2026.

The textile user can get protection against pathogenic or odour-causing microorganisms using this hygiene finish in different end uses.

The work is original. Very few references are available on zinc pyrithione. First, laboratory studies were done, and bacteriostatic properties of zinc pyrithione were determined quantitatively followed by bulk trial.

The purpose of this paper is to provide an overview of the context for strategies to overcome antimicrobial resistance in Australia, which may provide valuable learnings for other jurisdictions.

Non-systematic review of literature from websites of national, state and territory health departments and interviews with key stakeholders for Australian strategies to reduce antimicrobial resistance.

In July 2015 all states and territories in Australia adopted the National Antimicrobial Resistance Strategy 2015-2019, which is built on the World Health Organization policy package to combat antimicrobial resistance. This strategy represents “the collective, expert views of stakeholders on how best to combat antimicrobial resistance in Australia. It will also support global and regional efforts, recognising that no single country can manage the threat of antimicrobial resistance alone”. It combines quantitative and qualitative monitoring strategies with frameworks and guidelines to improve management of the use of antimicrobial resistant drugs. Prior to this, health services and states developed and implemented initiatives aimed at monitoring and improving prescribing practices. Development of the national strategy has encouraged and fostered debate within the Australian health system and a raft of new policy initiatives.

Surveillance strategies are in place to monitor impact and trends at jurisdictional and sector levels. However, actual impact on antimicrobial resistance and prescribing practices remains to be seen as existing initiatives are expanded and new initiatives implemented.

This overview of key Australian initiatives balancing quantitative and qualitative surveillance, accreditation, research, education, community awareness and price signals on antibiotic prescribing practices may be valuable to health systems in developing local strategies.

The authors provide an up to date overview of the context, strategies and aims of antimicrobial stewardship in Australia.

Antimicrobials may be incorporated into garments to protect the textiles, control malodour or to potentially reduce the spread of infection. Yet still not well understood is how antimicrobial-treated textiles may influence a person's resident microflora during wear, as limited in vivo testing has previously been carried out. The purpose of this paper is to assess whether normal skin microflora was altered as a result of contact with selected antimicrobial-treated fabrics.

Three selected antimicrobial-treated fabrics (i.e. Fabric 1: triclosan; Fabric 2: zinc pyrithione derivative; and Fabric 3: silver chloride and titanium dioxide) were placed on the forearm of participants (n=19). Bacterial counts obtained under treated and untreated fabrics following 24 hours of occlusion were compared. The antimicrobial efficacy of fabrics displayed in vitro was also compared with the activity displayed in vivo.

Two of the three fabrics (Fabrics 1 and 2) reduced bacterial populations on the skin following 24 hours occlusion compared to the matched control fabrics (Fabric 1: p<0.05; Fabric 2: p<0.001). Whereas, following occlusion with Fabric 3 bacterial populations were not significantly different than the matched control. The present study demonstrated that in vitro assessment of antimicrobial capacities of fabrics do not necessarily predict the effects of such fabrics during wear.

The paper highlights that in vivo studies are a necessary and important tool for understanding the interactions of an antimicrobial-treated fabric with the wearer's skin. As well, the new method developed can be used by other researchers to examine the potential impact on skin microflora due to contact with antimicrobial-treated textiles.

Glycidyl methacrylate/monochlorotriazinyl-β-cyclodextrin mixture (GMA/MCT-β-CD) is grafted onto cotton fabric by an irradiation technique that uses linear electron beam radiation for initiating the grafting reaction. The obtained grafted fabric (cell-g-GMA/MCT-β-CD) is loaded with chlorohexidin diacetate (an antimicrobial agent) and subjected to several washing cycles. Grafted cotton fabrics (before and after loading with the antimicrobial agent) and control cotton fabrics are characterized for antimicrobial activity against different kinds of bacteria and fungi by using the diffusion disk method.

Grafted fabrics that are loaded with an antimicrobial agent show very good antimicrobial activity in comparison with control and grafted fabrics which are not loaded with an antimicrobial agent. The results in this study also demonstrate that GMA/MCT-β-CD grafted fabrics that are loaded with an antimicrobial agent retain a good deal of their antimicrobial activity after five washings. Good retention of antimicrobial activity is due to the cavities that are present in the cyclodextrin moieties which are used to host and keep the antimicrobial agent.

The purpose of this paper is to investigate the effects of nano‐titanium dioxide and nano‐silicon dioxide particles on the mechanical and antimicrobial properties of denture base resin.

Nano‐titanium dioxide and nano‐silicon dioxide particles were introduced to heat‐curing denture base resin to prepare composites. Electronic universal testing machine and friction tester were used to test tensile strength and frictional resistance properties of the samples prepared, respectively; also, film adhesion method was used to test the in vitro antimicrobial activity against Candida albicans and Streptococcus mutans.

Addition of nano‐titanium dioxide particles could improve the antimicrobial property of denture base resin, and addition of nano‐silicon dioxide particles could improve the tensile strength and frictional resistance of denture base resin. Mixture of the two nano‐particles, at a certain ratio, could improve the tensile strength, frictional resistance and antimicrobial property of denture base resin to a certain extent.

Nano‐titanium dioxide and nano‐silicon dioxide denture base resin composites were obtained. The mechanical and antimicrobial properties of the composites were improved compared to the raw denture base resin.

Nano‐titanium dioxide and nano‐silicon dioxide denture base resin composites with excellent performance could be obtained. Longer service life, greater hardness and clearness helped improve the patients' quality of life. Limited work with respect to the improved denture base resin was performed, which could form the theme of a future study. The outcomes of the research reported here set a new milestone in the field of denture base resin.

The purpose of this paper is to improve surgical antimicrobial prophylaxis (SAP) prescribing in orthopaedic surgery using the model for improvement framework.

Orthopaedic patients receiving joint replacements, hip fracture repairs or open-reduction internal-fixation procedures were included. Antimicrobial(s); dose, time of administration and duration of SAP were evaluated for appropriateness based on the local SAP guidelines. After baseline data collection, a driver diagram was constructed with interventions devised for plan-do-study-act cycles. Data were fed back weekly using a point prevalence design (PPD). Interventions included SAP guideline changes, reminders and tools to support key messages.

SAP in 168 orthopaedic surgeries from 15 June 2016 to 31 January 2017 was studied. Prescribing appropriateness improved from 20 to 78 per cent. Junior doctor changeover necessitated additional education and reminders.

Due to constant staff changeover; continuous data collection, communication, education and reminders are essential to ensure continuous compliance with clinical guidance. Patients with hip fractures are difficult to weigh, requiring weight estimation for weight-based antimicrobial dosing. Unintended consequences of interventions included the necessity to change pre-operative workflow to accommodate reconstitution time of additional antimicrobials and inadvertent continuation of new antimicrobials post-operatively.

Rather than perform the traditional retrospective focused audit, we established a prospective, continuous, interventional quality improvement (QI) project focusing on internal processes within the control of the project team with rapid cyclical changes and interventions. The weekly PPD was pragmatic and enabled the QI project to be sustained with no additional resources.

The COVID-19 pandemic has popularized wearing face masks for personal protection. However, the protection afforded by a mask is decreased if an individual accidently touches the outer surface of the mask and then touches other parts of their face. To overcome this problem, antimicrobial masks have become commercially available. However, many are disposable and/or made from synthetic antimicrobial agents which have a negative impact on the environment. The purpose of this study was to create material for stitching antimicrobial masks that are reusable and natural.

The authors developed natural antimicrobial finishes from Azadirachata indica, Butea monosperma and Litchi chinensis leaves. The authors used biodegradable polyurethane binder and pad-dry-cure method to apply them on 100% cotton fabric. The authors used Fourier-transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscope (SEM) to confirm the application and ASTM E2149 to assess the efficacy and wash-resistance of the finish.

Fabric treated with leaves of A. indica, B. monosperma and L. chinensis showed 80%, 100 and 100% antimicrobial activity, respectively. All fabrics were washed 25 times in home laundry cycles and maintained 100% of their antimicrobial effect.

These findings highlight that B. monosperma and L. chinensis finishes on cotton fabric can be a used as a material for stitching antimicrobial, natural and reusable masks that provide more protection than traditional masks but do not pose the environmental concerns of disposable masks or synthetic finishes. This study can be furthered by performing more laundry cycles to determine if the finishes remain 100% effective beyond 25 cycles.

The purpose of this paper is to develop non-leaching and eco-friendly antimicrobial waterborne polyacrylates with excellent antibacterial properties by grafting antibacterial vinyl monomer, glycidyl methacrylate (GMA) modified polyhexamethylene guanidine hydrochloride (PHMG).

PHMG of different molecular weights were modified by GMA to synthesize antibacterial vinyl monomer, GMA-modified PHMG (GPHMG). Different content and molecular weights of GPHMG were used to synthesize antimicrobial waterborne polyacrylates through emulsion polymerization.

The addition of GPHMG gained by modifying PHMG showed little influence on thermal stability of the films, but decreased the glass transition temperature(Tg). Meanwhile, the tensile strength decreased, while the breaking elongation increased. The antibacterial properties of the antibacterial films with different GPHMG contents were studied, when GPHMG content was around 0.9 Wt.%, antibacterial films showed excellent antibacterial activity (antibacterial rate >= 99.99 per cent). When weight content of GPHMG in the films remained constant, antibacterial property of films increased first and then decreased with the increase of molecular weight of GPHMG. The structural antibacterial polymer film had more perdurable antibacterial activity than the blended one.

The grafting efficiency of GPHMG to antimicrobial waterborne polyacrylates could be further improved.

Antimicrobial waterborne polyacrylates with excellent antibacterial properties can be used to antibacterial coating and adhesive.

The antibacterial properties of films with different molecular weight of GPHMG were studied, and the durability and stability of antibacterial properties between structural antimicrobial films and blended antimicrobial films were also investigated by ring-diffusion method.