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The purpose of the research is to analyze the factors that determine the intention of small- and medium-sized enterprises (SMEs) to adopt the Metaverse. For this purpose, the analysis of the effort expectancy and performance expectancy of the constructs in relation to business satisfaction is proposed.

The analysis was performed on a sample of 182 Spanish SMEs in the technology sector, using a PLS-SEM approach for development. For the confirmation of the model and its results, an analysis with PLSpredict was performed, obtaining a high predictive capacity of the model.

After the analysis of the model proposed in this research, it is recorded that the valuation of the effort to be made and the possible performance expected by the companies does not directly determine the intention to use immersive technology in their strategic behavior. Instead, the results obtained indicate that business satisfaction will involve obtaining information, reducing uncertainty and analyzing the competition necessary for approaching this new virtual environment.

The study represents one of the first approaches to the intention of business behavior in the development of performance strategies within Metaverse systems. So far, the literature has approached immersive systems from perspectives close to consumer behavior, but the study of strategic business behavior has been left aside due to the high degree of experimentalism of this field of study and its scientific approach. The present study aims to contribute to the knowledge of the factors involved in the intention to use the Metaverse by SMEs interested in this field.

Ovarian cancer (OC) is the most common type of gynecologic cancer in the world with a high rate of mortality. Due to manifestation of generic symptoms and absence of specific biomarkers, OC is usually diagnosed at a late stage. Machine learning models can be employed to predict driver genes implicated in causative mutations.

In the present study, a comprehensive next generation sequencing (NGS) analysis of whole exome sequences of 47 OC patients was carried out to identify clinically significant mutations. Nine functional features of 708 mutations identified were input into a machine learning classification model by employing the eXtreme Gradient Boosting (XGBoost) classifier method for prediction of OC driver genes.

The XGBoost classifier model yielded a classification accuracy of 0.946, which was superior to that obtained by other classifiers such as decision tree, Naive Bayes, random forest and support vector machine. Further, an interaction network was generated to identify and establish correlations with cancer-associated pathways and gene ontology data.

The final results revealed 12 putative candidate cancer driver genes, namely LAMA3, LAMC3, COL6A1, COL5A1, COL2A1, UGT1A1, BDNF, ANK1, WNT10A, FZD4, PLEKHG5 and CYP2C9, that may have implications in clinical diagnosis.