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Despite their increasing importance in innovation, employment creation and economic growth, there is a dearth of theory-driven research on the financing and capital structure of new technology-based firms (NTBFs).¹ Hogan and Hutson (2005a) advance the High-Technology Pecking Order Hypothesis (HTPOH) to explain the role of equity in the financing of NTBFs in the software product sector. The HTPOH posits that NTBFs exhibit a hierarchical pattern of financing that gives precedence to internal sources, but if external financing is required, equity is preferred to debt. This study investigates the extent to which the genesis of the NTBF affects its financing patterns?

The purpose of this paper is to analyze this phenomenon and identify its determinants using data from Brazilian higher education institutions.

Based on a data set comprehending 2,230 university students from 70 different institutions across the country, the authors develop five Probit models to assess impacts related to individual traits and systemic conditions on five dependent dimensions: entrepreneurial activity, potential entrepreneurs, high-impact entrepreneurship, serial entrepreneurship and innovation-driven entrepreneurship.

The lack of significance in many of the variables included in estimations suggests that student entrepreneurship seems to be a rather random phenomenon in Brazil.

Findings pose challenges for student entrepreneurship, as targets for intervention are not clear.

Over the past decades, universities have been receiving an increasing demand to go beyond their role of producing science and technology to explore its knowledge potential to produce novel commercial applications. However, while there is a growing interest in ways to foster scientific academic entrepreneurship, universities also serve as a positive environment for student entrepreneurship training, knowledge sharing, testing ideas and learning. So far, the importance of student entrepreneurship has received far less attention than it likely deserves.

The paper aims to explore the nature of initiatives and strategies of inter-organizational cooperation to cross the valley of death in the biopharma industry.

The authors conducted an exploratory case study analysis in the Biopharma Innovation Ecosystem in Greater Boston Area (USA), which is one of the oldest, and most successful IE in the US, specialized in the Biopharma domain, by conducting a round of expert interviews with key informants in the area, chosen as representatives of the different types of actors engaged in the drug development processes at different stages.

Main findings suggest that cooperation can contribute to surviving the valley of death by reducing the barriers within the drug development pipeline through the promotion of strategic relationships among actors of different nature, including the establishment of government-led thematic associations or consortia, agreements between university and business support structures, proximity to venture capitalist and the promotion of a general culture of academic entrepreneurship within universities.

The authors believe that this paper contributes to the literature by shedding light on the nature of the specific cooperative initiative the barriers in drug development and help to survive the valley of the death.

The purpose of this paper is to discuss academic spinoffs (ASO) as an expression of the value creation of university technology transfer (TT) investments. More recently, scholars have emphasised intellectual capital’s (IC) importance, also for universities in obtaining competitive advantages and by creating value. Such spinoffs are key to regional development, as a primary aspect of universities’ IC.

The authors tested the aim through a sample of the University of Pisa’s spinoffs. The authors measured the value the university’s third mission investment generates on the area by means of entrepreneurship through two different approaches. First, the authors defined a multiplier of the TT investment (university TT multiplier) and then explored the IC components’ contributions to the ASOs’ enterprise value (EV).

The results show that the University of Pisa’s TT investments positively impact the local community through the spinoff system, both in economic terms and in IC. In the long term, these investments can enrich scientific humus and entrepreneurial mindsets.

This is an exploratory study of the University of Pisa’s impacts on the local economy. The results are limited to the context of Pisa and to the TT policy. Another limitation is the subjectivity of the EV estimation.

The results can have some practical implications. The large portfolio of university stakeholders (policymakers, families, students, companies, financiers, etc.) ask for information, especially on long-term results: in a simple way, the multiplier is able to communicate important feedbacks to support their decision-making process.

With the multiplier, the authors give a tool to measure the social enrichment.

In the study, the authors propose a new tool to measure the impact of the investment in TT on the local community.

The commercialization of research produced by universities constitutes a core facet of academic entrepreneurship (AE). Academic literature reveals the need to shed light on entrepreneurial processes in higher education institutions (HEIs). This study intends to fill this gap by researching the mechanisms for facilitating AE and the variables that can moderate the relationship between such mechanisms and AE in Portuguese HEIs.

Our research model aims to assess the mechanisms of academic entrepreneurship (AE) within a sample of 125 Portuguese public higher education institutions (HEIs). To test our research hypotheses, we employed a structural equation model (SEM) using the partial least squares (PLS) method. Additionally, our evaluation examines the potential moderating effects of incubator programs, support initiatives, and proof-of-concept programs (PoCs). Our research model seeks to evaluate the mechanisms for facilitating AE and explore the effects of including incubator programs, support initiatives, and PoCs as moderators. The seven variables (Research mobilization, Unconventionality, Industry collaboration, University policies, Incubator programs and support initiatives, Proof-of-concept programs, and academic entrepreneurship) were measured using a 7-point Likert scale.

The results revealed that different drivers of AE influence the creation and development of entrepreneurial activities. Our findings also show the moderating effects of incubator programs, support initiatives, and proof-of-concept programs on AE. We find that incubator programs, other support initiatives, and PoCs maintain a moderating effect on AE and benefit their respective HEIs.

The study examines only the Portuguese HEI context. Therefore, generalizing these results necessitates reservations. However, the responses came from various actors in HEIs, from different academic backgrounds and research interests. This makes the results more generalizable. Limitations are evident in external validity, given that we gathered the data over a relatively short period.

Observed factors are explored to gain a deeper understanding of their influence on the mechanisms of AE. The implications arise from the new perspective presented and the methodology used to identify mechanisms capable of fostering AE. We hope this research will encourage other researchers to study this topic further.

the engagement of universities at the global level should be emphasised in future policy. While universities in innovation systems often have a local focus, their engagement in innovation ecosystems transcends the boundaries of geographic locations.

PoCs had a significant positive moderating effect on the impact of research mobilization and university policies on AE. Thus, we find interactions between universities and industry boost AE. This study demonstrates how AE benefits HEIs by extending orientation towards mobilizing research, unconventional approaches, cooperation with industry, and university policy implementation. We thus advocate a new approach, demonstrating the influence that the mobility of research, unconventionality, industry collaboration, and university policies hold over AE.

University–industry technology transfer is growing at a rapid rate in China, involving both multinational and domestic companies. This chapter describes unique characteristics of Chinese National Technology Transfer Centers (NTTCs) and examines whether they can function as an effective policy instrument in promoting the commercialization of university research findings. Our qualitative and quantitative study finds that NTTCs are not by themselves an effective policy tool in accelerating the commercialization of university inventions. We found that universities without NTTCs can achieve the same or even greater success than those with NTTCs. We suggest that Chinese universities should mimic the Western approach by providing an attractive reward system and autonomy to technology management programs that stimulate their efforts in marketing patented technology.

By using the lens of effectuation and causation, this paper aims at exploring how the team is formed in high-tech academic spinoffs, by looking specifically at decisional heuristics in an academic context. Indeed, the team composition is a critical issue for the subsequent growth of the academic new venture: on the one hand, the scientific-centred knowledge of the academic entrepreneurs is one of the main elements that lay the foundation for the new venture; on the other hand, it has been widely recognized that the lack of market-related knowledge and experience often has detrimental effects on performance. Decisive is then to explore how team decisions pertaining to the team formation process are taken.

A qualitative methodology based on multiple case studies is adopted under an abductive approach.

Results shed light on how decisions pertaining to team formation are taken by academic entrepreneurs and with what effects on team composition, a fundamental element to foster the growth of academic new ventures. Specifically, this study derives some propositions about the adoption of effectuation and causation in the team formation process, their occurrence and sequence in the light of the scientific context in which academic new ventures spin out and the effects on the team composition.

This study contributes to the debate on academic entrepreneurs’ decisional heuristic and the use of effectuation or causation in the early stages of an academic new venture, by focusing on the team formation process. This study specifically considers three temporal micro-phases – the selection of founders before inception, the appointment of top management teams, and the integration of early employees after the inception – and whether the academic context influences the decisional heuristics. Managerial implications are also derived.

The purpose of this study is to investigate contemporary changes in the education system. In particular, an analysis of the mechanisms of coordination and communication involved in the process can show how different geographical factors with different relational mechanisms may contribute to the creation of a new academic entrepreneurship.

The authors propose a methodology with two-step approach. In the first part of the paper, they use a theoretical approach to carry out a longitudinal study of academic literature on the topics of “entrepreneurial university,” “academic entrepreneurship” and “spin-off organizations.” In the second part, they use cross-database analysis to theorize the main aspects of recent developments in higher education in Italy. To this end, the authors use three public and open-access databases on spin-offs, universities and higher education institutions and incubators in Italy.

First, issues relating to the formation and best practices of entrepreneurial universities are discussed, based on the works of researchers from 25 countries. Second, a hypothesis is put forward to suggest that the organizational model of entrepreneurial university affects microeconomic competitiveness. Third, a case study of Italian spin-off organizations suggests that the number of incubators and spin-offs, and the type of academic knowledge, all directly affect the entrepreneurial university.

This paper aims to examine the role of the university in the modern economic system. The originality of this investigation lies in its ability to offer a picture and first analysis of the main actors and of the entrepreneurial university system.

Focusing on the adoption of Total Quality Management (TQM) principles in universities, this research paper explores how the “soft” dimensions of TQM trigger its “hard” dimensions considering them at the individual (micro-) and the university (meso-), and eventually at cluster (system-), levels.

Adopting a qualitative approach, this study presents an in-depth, longitudinal case study of University of Siena, one of the oldest Italian universities, that has been at the core of the research-based cluster on vaccines, today converged in the Tuscan Life Science Cluster. In particular, data were collected between 2018 and February 2022 and consists of archival data (press articles, websites, books), nine interviews to key informants, multiyear experience of the Life Sciences sector by two of the authors and other material put at disposal by university offices, and emails. Data analysis relied on a timeline, a coding procedure that considered three levels of analysis (individual, organization and cluster). Finally, the authors looked at the “how” and “why” the emerged themes have contributed to academic excellence.

This paper unveils how “soft” and “hard” sides of TQM are blended across multiple levels for reaching academic excellence. The grounded model emerged enlightens the importance of an individual “soft” dimension, academic passion (composed by its three subdimensions of individual research, teaching and entrepreneurial passion) and also sheds light on the organizational “soft” and “hard” sides that the university has been able to design for encouraging research, teaching and third mission quality. Academic excellence has been possible thanks to the capitalization of the individual and organizational “soft” sides into real outcomes as represented by the organizational and individual “hard” sides.

The paper suggests the importance of TQM principles applied at universities' level, providing an in-depth description of “soft” and “hard” sides dimensions of TQM and their impact on all the three pillars of academic excellence. The study findings suggest implications for managers and professionals in the higher education domain as well as for policymakers emphasizing the importance of supporting the individual and organizational soft sides of TQM. The authors provide practical implications recommending universities to consider not only the organizational dimensions but also individual ones when pursuing higher education excellence. In particular, individual passion plays a crucial role and universities need to identify ways of nurturing it. The authors also recommend policymakers to think about new ways to sustain universities as crucial actors in boosting a cluster development, as well as to consider higher education institutions, especially in more rural areas, as a privileged player not only capable of nurturing academic excellence but also able of creating an internationally renowned cluster.

TQM principles have been intensively analysed from an industrial perspective focusing on manufacturing and services, while this paper focuses on TQM in universities, presenting a grounded model that blends the individual and organizational “soft” and “hard” sides.

The purpose of this paper is to understand different institutional mechanisms for promoting effective innovation diffusion and maximizing spillovers from fruitfulness of university‐industry linkages.

The approach involved the content analysis of university documents and in‐depth interviews with university personnel. The paper investigated the types of changes which had been instituted by selected universities in regards to the management of invention disclosure and patent licensing procedures, policies for new business startups by faculty and graduates. The paper then studies how university incentive structures have been reshaped to encourage and facilitate engagement with industry.

The types of changes have been instituted by select universities enhance research commercialization capacity in regards to the management of invention disclosure and patent licensing, policies for new business startups by faculty and graduates, and provision of seed capital, training and incubator facilities, especially the relationship between technology transfer offices and university administration, as well as faculty; how university incentive structure has been reshaped to encourage and facilitate engagement with industry; how gross royalties and/or net royalty income are distributed between university and faculty.

This paper describes the important role of institutional underpinnings for building commercial linkages. It also explores what university policies and institutions shape the nature and fruitfulness of innovation diffusion in China.