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Title: Optical sensor with layered plasmon structure for enhanced detection of chemical groups by SERSApplicant: Poponin Vladimir (US)Patent number: US2006034729Publication date: 16 February 2006
An optical sensor and method for use with a visible-light laser excitation beam and a Raman spectroscopy detector, for detecting the presence chemical groups in an analyte applied to the sensor are disclosed. The sensor includes a substrate, a plasmon resonance mirror formed on a sensor surface of the substrate, a plasmon resonance particle layer disposed over the mirror, and an optically transparent dielectric layer about 2-40nm thick separating the mirror and particle layer. The particle layer is composed of a periodic array of plasmon resonance particles having: a coating effective to binding analyte molecules; substantially uniform particle sizes and shapes in a selected size range between 50-200nm; and a regular periodic particle-to-particle spacing less than the wavelength of the laser excitation beam. The device is capable of detecting analyte with an amplification factor of up to 1012-1014 allowing detection of single analyte molecules.
Title: Waveguide-based optical chemical sensorApplicant: Grace Karen M (US); Swanson Basil I (US); Honkanen Seppo (US)Patent number: US2005078903Publication date: 14 April 2005
The invention provides an apparatus and method for highly selective and sensitive chemical sensing. Two modes of laser light are transmitted through a waveguide, refracted by a thin film host reagent coating on the waveguide, and analyzed in a phase sensitive detector for changes in effective refractive index. Sensor specificity is based on the particular species selective thin films of host reagents which are attached to the surface of the planar optical waveguide. The thin film of host reagents refracts laser light at different refractive indices according to what species are forming inclusion complexes with the host reagents.
Title: Optical fiber array biochip based on white-light reflectrometric interference spectroscopyApplicant: Tan Yushan (CN); Tan Hong (US); Chen Duanjun (US)Patent number: EP1645865Publication date: 12 April 2006
The invention discloses a kind of optical fibre micro-fluidic biochip that is used to detect the existence and/or density change of certain biological or chemical materials. This bio-chip employs optical fibres as sensors. One or multiple layers of materials are immobilized at one end surface of the fibre, where the immobilized materials are of different properties both from the fibre and from the materials to be detected. At least one of the immobilized layers is made of such a material that is complementary to the biological or chemical material to be detected. When molecules of the biological or chemical material bind onto the complementary material layer, spectral interference distribution patterns of light beams reflected from the fibre-tip layers are shifted. This kind of spectrum shift is then used to, quantitatively or qualitatively, analyze the density, binding speed, as well as geometry of the sample molecules. By adding many fibres into a linear array or a two-dimensional array and using an N:1 optical fibre coupler, a device can be built that is capable of detecting multiple properties of a single sample (analyte) or multiple properties of multiple samples (analytes).
Title: Diffractive optical position detectorApplicant: Asylum Res Corp.Patent number: US2006072185Publication date: 06 April 2006
An apparatus and method for measuring optically the position or angle of a variety of objects or arrays of objects, including cantilevers in scanning probe microscopy, micromechanical biological and chemical sensors and the sample or a probe in surface profilometry. The invention involves the use of one or more diffractive optical elements, including diffraction gratings and holograms, combined with conventional optical elements, to form a plurality of light beams, each with a selectable shape and intensity, from a single light source, reflect the beams off mechanical objects and process the reflected beams, all to the end of measuring the position of such objects with a high degree of precision. The invention may also be used to effect mechanical changes in such objects. Devices with these improvements have numerous applications, including molecular force measurements, atomic force microscopy and manipulation technology, lithographic manufacturing, nanometer scale surface profiling and other aspects of nanotechnology.
Title: Microfluidic apparatus with integrated porous-substrate/sensor for real-time (bio) chemical molecule detectionApplicant: Intel Corp. (US)Patent number: TW249433BPublication date: 21 February 2006
Microfluidic apparatus including integrated porous substrate/sensors that may be used for detecting targeted biological and chemical molecules and compounds. In one aspect, upper and lower microfluidic channels are defined in respective halves of a substrate, which are sandwiched around a porous membrane upon assembly. In another aspect, the upper and lower channels are formed such that a portion of the lower channel passes beneath a portion of the upper channel to form a cross-channel area, wherein the membrane is disposed between the two channels. In various embodiments, one or more porous membranes are disposed proximate to corresponding cross-channel areas defined by one or more upper and lower channels, the porous membrane may also have sensing characteristics, such that it produces a change in an optical and/or electronic characteristic. Accordingly, the apparatus may further include instrumentation or detection equipment to measure the changes, such as optic- based detectors and electronic instrumentation.