The association between dietary fatty acid intake and gallstone disease: a case-control study
Abstract
Purpose
The present study was designed with the aim of investigating the association between different dietary fatty acids and the risk of Gallstone disease (GSD).
Design/methodology/approach
The authors conducted a hospital-based, case-control study on 189 newly diagnosed GSD patients and 342 controls. Total fat and individual fatty acids, including monounsaturated fatty acids (MUFA), polyunsaturated fatty acids (PUFA) and saturated fatty acids (SFA) were assessed.
Findings
Increased risk of GSD was observed in the highest tertile of total dietary fat (OR = 1.6, CI 95%: 1.09–2.8, p = 0.002) in the fully adjusted model. Comparing the highest intake with the first tertile, showed that intake of PUFA was significantly associated with a decrease in the risk of GSD (OR = 0.87, CI 95%: 0.5–1.5, p = 0.001), and intake of SFA (OR = 1.3, CI 95%: 1.07–2.2, p = 0.001) was associated with an increase in the risk of gallstones.
Originality/value
In this study, for the first time, we explored the role of dietary fatty acids in the development of GSD, including PUFA, MUFA and SFA. Their results could help elucidate the association between fatty acids and GSD more precisely and may be beneficial in prevention and treatment of cholelithiasis.
Keywords
Acknowledgements
Authors have no acknowledgments to declare.
Declarations: Ethics approval and consent to participate. Informed written consent was obtained from participants. The protocol of the present study was approved by Research Institute of Gastroenterology and Liver Diseases Ethics Committee (IR.SBMU.RIGLD.REC.1396.159).
Availability of data and material: The datasets analyzed in the current study are available from the corresponding author on reasonable request.
Conflict of interest: The authors declare that they have no competing interests.
Authors’ contributions: Zahra Yari – Corresponding Author, Formal analysis, Project administration, Writing – original draft, Writing – review and editing; Amir Sadeghi, Conceptualization, Writing – review and editing; Negar Raissi-Dehkordi, Conceptualization, Writing – original draft; Azita Hekmatdoost, Conceptualization, Writing – review and editing, Project administration; Moloud Ghorbani, Methodology; Reyhaneh Rastegar, Formal analysis; Mohammadreza Zali, Methodology; Nastaran Raissi-Dehkordi, Methodology, Writing – original draft.
Citation
Sadeghi, A., Raissi-Dehkordi, N., Ghorbani, M., Rastegar, R., Zali, M., Raissi-Dehkordi, N., Yari, Z. and Hekmatdoost, A. (2025), "The association between dietary fatty acid intake and gallstone disease: a case-control study", Nutrition & Food Science, Vol. ahead-of-print No. ahead-of-print. https://doi.org/10.1108/NFS-06-2024-0196
Publisher
:Emerald Publishing Limited
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