Keywords
Citation
(2006), "Gaba in Autism and Related Disorders (International Review of Neurobiology, Volume 71)", International Journal of Health Care Quality Assurance, Vol. 19 No. 4. https://doi.org/10.1108/ijhcqa.2006.06219dae.003
Publisher
:Emerald Group Publishing Limited
Copyright © 2006, Emerald Group Publishing Limited
Gaba in Autism and Related Disorders (International Review of Neurobiology, Volume 71)
Gaba in Autism and Related Disorders (International Review of Neurobiology, Volume 71) Dirk DhosscheDepartment of Psychiatry & Human Behavior, University of Mississippi Medical CenterElselvierISBN 0-12-366872-7
Keywords: Gaba function, Developmental signals, Developmental disorders
The book presents new findings on common genetic mechanisms in Rett syndrome, Angelman syndrome, and autism and includes information on the shared genetic risk factors between autism and major mental disorders
Gamma-aminobutyric acid (GABA) was discovered in the brain in 1950 by Eugene Roberts. GABA is now considered one of the most important neurotransmitters and developmental signals. Knowledge on the complexity of GABA function is increasing exponentially. This volume covers basic research on GABA in the developing brain as it may relate to onset of autism and related developmental disorders. The evidence that dysfunction of GABA and related molecules is associated with autism is limited but expanding and seems to converge. Pertinent data are reviewed in this book and new research avenues in the basic and clinical arenas are described. The topics are of imminent interest to basic and clinical researchers as well as interested clinicians.
Contents include:
Autism: neuropathology, alterations of the GABAergic system, and animal models. The role of GABA in the early neuronal development. GABAergic signaling in the developing cerebellum. Insights into GABA functions in the developing cerebellum. Role of GABA in the mechanism of the onset of puberty in non-human primates. Rett syndrome. GABAergic cerebellar system in autism. Reelin Glycoprotein in autism and schizophrenia. Is there a connection between autism, Prader-Willi syndrome, catatonia and GABA? The role of GABA in prenatal alcohol exposure. Implications for treatment of mental illness. immunological Findings in Autism; GABA-A receptor mutations in epilepsy and other disorders. Shared chromosomal susceptibility regions between autism and other mental disorders.