The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease

Citation

(2012), "The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease", Clinical Governance: An International Journal, Vol. 17 No. 4. https://doi.org/10.1108/cgij.2012.24817daa.003

The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease

Article Type: Reviews of effectiveness From: Clinical Governance: An International Journal, Volume 17, Issue 4

Cholesterol Treatment Trialists’ (CTT) CollaboratorsThe effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trialsLancet2012Published online May 17

This meta-analysis of individual patient data concluded that in individuals with five-year risk of major vascular events lower than 10 per cent, each 1mmol/L reduction in low-density lipoprotein cholesterol produced an absolute reduction in major vascular events of about 11 per 1,000 over five years. The authors’ conclusions are likely to be reliable.