Effect of metformin on cardiovascular events and mortality

Citation

(2012), "Effect of metformin on cardiovascular events and mortality", Clinical Governance: An International Journal, Vol. 17 No. 2. https://doi.org/10.1108/cgij.2012.24817baa.011

Effect of metformin on cardiovascular events and mortality

Effect of metformin on cardiovascular events and mortality

Article Type: Reviews of effectiveness From: Clinical Governance: An International Journal, Volume 17, Issue 2

Lamanna, C., Monami, M., Marchionni, N., Mannucci, E.,Effect of metformin on cardiovascular events and mortality: a meta-analysis of randomized clinical trials,Diabetes Obesity and Metabolism,2011,Vol. 13 No. 3,pp. 221-228

This review concluded that the evidence seemed to exclude any overall harmful effect of metformin on cardiovascular risk and suggested a possible benefit versus placebo/no treatment. Limitations with the included evidence and a lack of reporting of some aspects of the review process limit the reliability and generalisability of the results. The cautious conclusion and recommendations for research seem appropriate.