Citation
(2011), "Testing for cytochrome P450 polymorphisms in patients with schizophrenia", Clinical Governance: An International Journal, Vol. 16 No. 1. https://doi.org/10.1108/cgij.2011.24816aae.004
Publisher
:Emerald Group Publishing Limited
Copyright © 2011, Emerald Group Publishing Limited
Testing for cytochrome P450 polymorphisms in patients with schizophrenia
Testing for cytochrome P450 polymorphisms in patients with schizophrenia
Article Type: Reviews of effectiveness From: Clinical Governance: An International Journal, Volume 16, Issue 1
Fleeman, N., McLeod, C., Bagust, A., Beale, S., Boland, A., Dundar, Y., Jorgensen, A., Payne, K., Pirmohamed, M., Pushpakom, S., Walley, T., de Warren-Penny, P., Dickson, R.,The clinical effectiveness and cost-effectiveness of testing for cytochrome P450 polymorphisms in patients with schizophrenia treated with antipsychotics: a systematic review and economic evaluation.Health Technology Assessment2010Vol. 14 No. 3pp. 1-157
This review concluded that tests for determining the genotypes for cytochrome P450 polymorphisms appeared to be highly accurate, but were not always well reported. There was limited research on the clinical validity of these tests for adults entering antipsychotic treatment for schizophrenia and no firm conclusions were possible. There were no completed studies on their clinical utility. These conclusions are likely to be reliable.