TY  - JOUR
AB  - Purpose The purpose of this paper is to verify the possibility of ultrasonic intensification of drug dissolution of cholesterol calculi of the gallbladder using conventional ultrasound frequency and intensity from 0.1 to 0.5 W/cm2.Design/methodology/approach For research purposes, the physical model was developed containing pig bile, pig liver, pigskin, fat and muscles, as well as human cholesterol calculus removed by surgery and a drug with ursodeoxycholic acid.Findings The studies have shown the possibility of accelerating the drug dissolution of calculi of the gallbladder with ultrasound exposure. The ultrasound intensity of 0.4 W/cm2 is the most preferable to intensify the dissolution of calculus.Originality/value The results will be used to advance with development of the device and methodology for ultrasonic intensification of drug dissolution of gallbladder calculi.
VL  - 40
IS  - 3
SN  - 0260-2288
DO  - 10.1108/SR-12-2019-0301
UR  - https://doi.org/10.1108/SR-12-2019-0301
AU  - Dikman Ekaterina
AU  - Soldatov Alexey
AU  - Chirev Anatoly
PY  - 2020
Y1  - 2020/01/01
TI  - The study of the possibility of drug dissolution of gallbladder calculi
T2  - Sensor Review
PB  - Emerald Publishing Limited
SP  - 363
EP  - 366
Y2  - 2024/04/25
ER  -