The study of the possibility of drug dissolution of gallbladder calculi

Abstract

Purpose

The purpose of this paper is to verify the possibility of ultrasonic intensification of drug dissolution of cholesterol calculi of the gallbladder using conventional ultrasound frequency and intensity from 0.1 to 0.5 W/cm².

Design/methodology/approach

For research purposes, the physical model was developed containing pig bile, pig liver, pigskin, fat and muscles, as well as human cholesterol calculus removed by surgery and a drug with ursodeoxycholic acid.

Findings

The studies have shown the possibility of accelerating the drug dissolution of calculi of the gallbladder with ultrasound exposure. The ultrasound intensity of 0.4 W/cm² is the most preferable to intensify the dissolution of calculus.

Originality/value

The results will be used to advance with development of the device and methodology for ultrasonic intensification of drug dissolution of gallbladder calculi.

Citation

Dikman, E., Soldatov, A. and Chirev, A. (2020), "The study of the possibility of drug dissolution of gallbladder calculi", Sensor Review, Vol. 40 No. 3, pp. 363-366. https://doi.org/10.1108/SR-12-2019-0301