Investigations on the antimicrobial activity of chitosan/PVA nanoparticle loaded nanofibers
Research Journal of Textile and Apparel
ISSN: 1560-6074
Article publication date: 10 May 2022
Issue publication date: 18 January 2024
Abstract
Purpose
In the past decade, the biopolymeric properties of chitosan (CH) have been largely exploited for various applications. This paper aims to study the use of CH in its nanoform, i.e. as nanofibers blended with polyvinyl alcohol (PVA) for various antimicrobial applications in detail. In particular, their ability toward bacterial growth inhibition, in vitro drug release and their biocompatibility toward tissue growth have been investigated in detail.
Design/methodology/approach
Electrospinning technique was adapted for depositing CH/PVA blended nanofilms on the silver foil under optimized conditions of high voltage. Three different concentrations of blended nanofiber samples were prepared and their antimicrobial properties were studied.
Findings
The bead diameter and average diameter of blended nanofibers increase with CH concentration. Antibacterial activity increases as CH concentration increases. Increased hydrophilicity in CH-enriched samples contributes to a higher drug release profile.
Originality/value
To the best of the authors’ knowledge, chick chorioallantoic membrane assay analysis has been carried out for the first time for CH/PVA films which shows that CH/PVA blends are biocompatible. CH after being converted as nanoparticles exhibits higher drug release rate by in vitro method.
Keywords
Acknowledgements
Conflict of interest: All authors declare that they have no conflicts of interest.
Citation
Selvaraj, S.K., B., S., S., S. and B., S.K. (2024), "Investigations on the antimicrobial activity of chitosan/PVA nanoparticle loaded nanofibers", Research Journal of Textile and Apparel, Vol. 28 No. 1, pp. 120-132. https://doi.org/10.1108/RJTA-11-2021-0134
Publisher
:Emerald Publishing Limited
Copyright © 2022, Emerald Publishing Limited