Hepatotoxicity of methoxychlor and camel milk restoration

Abstract

Purpose

The purpose of this paper is to investigate the restoration effect of camel's milk against methoxychlor induced liver toxicity.

Design/methodology/approach

The present study was carried out to investigate the restoration effect of camel's milk against methoxychlor induced liver toxicity.

Findings

Methoxychlor (MXC) caused a significant increase in serum transaminases (aspartate transaminase and alanine transaminase) and alkaline phosphatase, while MXC induced a significant reduction in total protein and albumin levels. MXC significantly inhibited lipid peroxidation and markedly enhanced glutathione in liver homogenate. Pathological damages as degeneration and coagulative necrosis of hepatocytes were established in liver. Newly formed bile ducteules denotes neoplastic changes in the portal tract with abnormal mitotic pattern were associated with the long-term exposure.

Originality/value

The present study concluded that camel milk treatment may play a protective role against methoxychlor-induced liver damage in rats.

Citation

Elsharkawy, E.E., El-Nisr, N.A., Wahba, N.M. and Elsherif, W.M. (2022), "Hepatotoxicity of methoxychlor and camel milk restoration", Nutrition & Food Science, Vol. 52 No. 3, pp. 483-496. https://doi.org/10.1108/NFS-12-2020-0469