This study aims to examine the effect of lesser yam-based cookies on glucagon-like peptide-1 (GLP-1), blood glucose and lipid profile in overweight and obese individuals.
This was an experimental study on overweight or obese adults aged 21-50 years old. The intervention was done by giving 87g of cookies made with lesser yam flour in combination with wheat flour (80 and 20 per cent, respectively) for six weeks. Anthropometric measures, fasting plasma glucose, lipid and GLP-1 were measured before and after the intervention.
There were no changes in anthropometric measurements and glucose level after the intervention (p > 0.05). However, plasma low density lipoprotein (LDL) and total cholesterol decreased after the intervention (p = 0.033 and p = 0.035, respectively). Although fasting GLP-1 level (p = 0.121) was unchanged, we found that the slight changes in GLP-1 concentration was associated with changes in LDL and total cholesterol (p = 0.002 and p = 0.001, respectively).
The lesser yam-based cookies reduced fasting plasma LDL and total cholesterol, but not glucose level after six weeks of intervention. Additionally, reduction of LDL and total cholesterol level was negatively associated with the changes in GLP-1 level.
Disclosure of potential conflicts of interest: This paper has received research grants from Universitas Gadjah Mada including Junior Investigator Grant and Department of Nutrition and Health Research Grant. The authors declare that they have no conflict of interest.
Research involving human participants and/or animal: All procedures performed in this study involving human were in accordance with the ethical standards of the institution at which the studies were conducted. In this study, the ethical approval was obtained from Medical and Health Research Ethics Committee, Faculty of Medicine Universitas Gadjah Mada – Dr Sardjito General Hospital.
Informed consent: Informed consent was obtained from all individual participants included in the study.
Luglio, H., Fitria, A., Kusumawardhani, D., Amalia, R., Hapsari, D., Susilowati, R. and Sunarti, S. (2016), "Lesser yam (dioscorea esculenta) based cookies improves lipid profile in overweight/obese adults with an ad libitum diet via glucagon like peptide 1", Nutrition & Food Science, Vol. 46 No. 3, pp. 336-343. https://doi.org/10.1108/NFS-10-2015-0131Download as .RIS
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