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Fermented rice bran extract improves dyslipidemia in rodents

Bira Arumndari Nurrahma (Department of Nutrition and Health, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia)
Mega Febia Suryajayanti (Department of Nutrition and Health, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia)
Anggi Laksmita Dewi (Department of Nutrition and Health, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia)
Zunamilla Khairia (Department of Nutrition and Health, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia)
Rio Jati Kusuma (Department of Nutrition and Health, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia)
Perdana S.T. Suyoto (Department of Nutrition and Health, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia and Center for Health and Human Nutrition, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia)

Nutrition & Food Science

ISSN: 0034-6659

Article publication date: 12 March 2018

184

Abstract

Purpose

The study aims to investigate the potency of fermented rice bran extract as anti-hypercholesterolemia product by looking at its effect on lipid profile levels and blood glucose levels in dyslipidemia model rats.

Design/methodology/approach

Rice bran was fermented using Rhizopus oligosporus-contained tempeh mold extracted using distilled water. Twenty-four Sprague Dawley rats were divided into a control group and hypercholesterolemia groups. Hypercholesterolemia, also known as dyslipidemia, was induced with fructose-supplemented high-fat diet. Rats induced with dyslipidemia received three different fermented rice bran extract doses, 0 (negative) 1102.5 mg/kgBW/day (FRBE 1) and 2205 mg/kgBW/day (FRBE 2). Blood was collected before and after four weeks of treatment for lipid profile and blood glucose analysis.

Findings

FRBE 2 had significantly lower total cholesterol (101.6 ± 3.3 vs 187.6 ± 3.7 mg/dL), triglyceride (83.3 ± 2.8 vs 130.7 ± 3.4 mg/dL) and LDL level (27.9 ± 1.7 vs 76.7 ± 1.5 mg/dL) but higher HDL level (64.1 ± 3.0 vs 25.5 ± 1.2 mg/dL) compared to the negative group (p < 0.001). Provision of fermented rice bran showed dose-response relationship in all blood lipid markers.

Originality/value

This study was the first to investigate the effectivity of Rhizopus sp.-fermented rice bran extract to improve glucose and lipid profile.

Keywords

Acknowledgements

This study was funded by the Indonesian Ministry of Research, Technology and Higher Education. The authors declare no conflict of interest.

Citation

Nurrahma, B.A., Suryajayanti, M.F., Dewi, A.L., Khairia, Z., Kusuma, R.J. and Suyoto, P.S.T. (2018), "Fermented rice bran extract improves dyslipidemia in rodents", Nutrition & Food Science, Vol. 48 No. 2, pp. 375-383. https://doi.org/10.1108/NFS-08-2017-0167

Publisher

:

Emerald Publishing Limited

Copyright © 2018, Emerald Publishing Limited

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