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Selected natural agents used for cholesterol controls

Nurul Hazwani Abdul Latif (Department of Pharmaceutical Technology, Faculty of Pharmacy, International Islamic University Malaysia, Jalan Sultan Ahmad Shah, Kuantan, Pahang, Malaysia)
Muhammad Taher (Department of Pharmaceutical Technology, Faculty of Pharmacy, International Islamic University Malaysia, Jalan Sultan Ahmad Shah, Kuantan, Pahang, Malaysia)
Juliana Md Jaffri (Department of Pharmaceutical Technology, Faculty of Pharmacy, International Islamic University Malaysia, Jalan Sultan Ahmad Shah, Kuantan, Pahang, Malaysia)
Mohamad Shahreen Amri (Department of Pharmaceutical Technology, Faculty of Pharmacy, International Islamic University Malaysia, Jalan Sultan Ahmad Shah, Kuantan, Pahang, Malaysia)
Muhammad Badri Abdul Kudos (Department of Pharmaceutical Technology, Faculty of Pharmacy, International Islamic University Malaysia, Jalan Sultan Ahmad Shah, Kuantan, Pahang, Malaysia)
Wan Mohd Azizi Wan Sulaiman (Department of Basic Medical Science, Faculty of Pharmacy, International Islamic University Malaysia, Jalan Sultan Ahmad Shah, Kuantan, Pahang, Malaysia)
Deny Susanti (Department of Chemistry, Faculty of Science, International Islamic University Malaysia, Jalan Sultan Ahmad Shah, Kuantan, Pahang, Malaysia)

Nutrition & Food Science

ISSN: 0034-6659

Article publication date: 12 March 2018

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Abstract

Purpose

Various studies suggest that some of natural agents create a specific action of hypocholesterolemic effect. Considering this fact, the aim of this paper is to work on describing selected natural agents that may reduce cholesterol concentrations by different mechanism of actions.

Design/methodology/approach

The advantages, phytochemical components and the mechanisms of the agents were reviewed and supported from the findings of the in vitro, double-blind and clinical studies from published journals, books and articles. The journals used in this review were published between 1987 and 2016, and are available from PubMed, ScienceDirect and Google Scholar.

Findings

Plant stanols and sterols, turmeric, fenugreek, avocado, tomato, artichoke, red yeast rice and garlic showed a positive effect in maintaining cholesterol levels by specific mechanisms or actions. These agents each had a specific action in creating a hypocholesterolemic effect either by inhibition of the enzyme significant to the synthesis process, disturbing the absorption of cholesterol, conversion of cholesterol to other related forms and through the reduction of the oxidative stress.

Research limitations/implications

However, this field still needs more studies as, currently, there is not any detailed information regarding the main active ingredients responsible for the mechanism to reduce cholesterol levels in humans.

Originality/value

This paper enlightens the authors’ understanding of some natural agents that have the potential to be used in controlling cholesterol.

Keywords

Acknowledgements

The authors are grateful for the funding support by the International Islamic University through Research Initiative Grant Scheme (RIGS16-289-0453).

Citation

Abdul Latif, N.H., Taher, M., Md Jaffri, J., Amri, M.S., Abdul Kudos, M.B., Wan Sulaiman, W.M.A. and Susanti, D. (2018), "Selected natural agents used for cholesterol controls", Nutrition & Food Science, Vol. 48 No. 2, pp. 301-317. https://doi.org/10.1108/NFS-06-2017-0128

Publisher

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Emerald Publishing Limited

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