Improvement in fasting blood sugar, anthropometric measurement and hs-CRP after consumption of epigallocatechin-3-gallate (EGCG) in patients with type 2 diabetes mellitus

Said Hadi (AJA University of Medical Sciences, Tehran, Iran)
Meysam Alipour (Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran)
Vahideh Aghamohammadi (Department of Nutrition, Khalkhal University of Medical Sciences, Khalkhal, Iran)
Sahar Shahemi (National Nutrition and Food Technology Research Institute, Tehran, Iran)
Fatemeh Ghafouri-Taleghani (Mashhad University of Medical Sciences, Mashhad, Iran)
Niloufar Pourjavidi (Islamic Azad University Science and Research Branch, Tehran, Iran)
Mona Foroughi (National Nutrition and Food Technology Research Institute, Tehran, Iran)
Mackaan Chraqipoor (AJA University of Medical Sciences, Tehran, Iran)

Nutrition & Food Science

ISSN: 0034-6659

Publication date: 16 August 2019

Abstract

Purpose

The epigallocatechin gallate (EGCG) effect in diabetes has been investigated in animal studies, but results of clinical trials are inconsistent. Thus, this study aims to evaluate the effects of EGCG supplementation in patients with type 2 diabetes mellitus (T2DM).

Design/methodology/approach

A total of 50 patients with T2DM were recruited in a double-blind, randomized, placebo-controlled trial. The eligible participants were randomly allocated to EGCG (n = 25) and placebo (n = 25) groups. The EGCG group received two capsules of EGCG (each capsule contained 150 mg; Shari Made®, Iran) and placebo group was administered two capsules of placebo (starch) for eight weeks. A three-day 24-h dietary recall and anthropometric and laboratory measurements were carried out at the beginning and the end of the study.

Findings

At the end of the trial, weight and body mass index (BMI) were decreased significantly in both groups, but the reduction was not statistically significant between the two groups. Fasting blood sugar decreased significantly in EGCG group. No significant between-group and within-group differences were found in insulin, homeostatic model assessment of insulin resistance (HOMA-IR) and the quantitative insulin sensitivity check index values. The high-sensitive C-reactive protein (hs-CRP) was significantly reduced in the EGCG group (4.13 ± 0.48-3.93 ± 0.50, p = 0.003) compared to baseline.

Originality/value

This study showed that consuming 300 mg/day of EGCG for eight weeks in patients with T2DM caused a significant decrease in fasting blood glucose, body weight, BMI and hs-CRP compared to baseline. Therefore, the EGCG supplementation may improve glycemic control, anthropometric and inflammation status in T2DM.

Keywords

Acknowledgements

Funding: This study was supported by AJA University of Medical Sciences, Tehran, Iran.

Conflict of interest: The authors have declared that there is no conflict of interest.

Citation

Hadi, S., Alipour, M., Aghamohammadi, V., Shahemi, S., Ghafouri-Taleghani, F., Pourjavidi, N., Foroughi, M. and Chraqipoor, M. (2019), "Improvement in fasting blood sugar, anthropometric measurement and hs-CRP after consumption of epigallocatechin-3-gallate (EGCG) in patients with type 2 diabetes mellitus", Nutrition & Food Science, Vol. 50 No. 2, pp. 348-359. https://doi.org/10.1108/NFS-04-2019-0126

Publisher

:

Emerald Publishing Limited

Copyright © 2019, Emerald Publishing Limited

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