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The prophylactic potential of Zingiber officinale flowers and leaves extract to mitigate hyperglycemia in Sprague Dawley rats

Saira Tanweer (National Institute of Food Science and Technology, Faculty of Food, Nutrition and Home Sciences, University of Agriculture Faisalabad, Faisalabad, Pakistan and Department of Food Science and Technology, Faculty of Agriculture and Environment, The Islamia University of Bahawalpur, Bahawalpur, Pakistan)
Tariq Mehmood (National Institute of Food Science and Technology, Faculty of Food, Nutrition and Home Sciences, University of Agriculture Faisalabad, Faisalabad, Pakistan and Faculty of Engineering and Technology, Khwaja Fareed University of Engineering and Information Technology, RahimYar Khan, Pakistan)
Saadia Zainab (Department of Food Engineering, Faculty of Agricultural Engineering and Technology, University of Agriculture Faisalabad, Faisalabad, Pakistan and College of Food Science and Technology, Henan University of Technology, Zhengzhou, China)
Zulfiqar Ahmad (Department of Food Science and Technology, Faculty of Agriculture and Environment, The Islamia University of Bahawalpur, Bahawalpur, Pakistan)
Muhammad Ammar Khan (Department of Food Science and Technology, Faculty of Agriculture and Environment, The Islamia University of Bahawalpur, Bahawalpur, Pakistan)
Aamir Shehzad (National Institute of Food Science and Technology, Faculty of Food, Nutrition and Home Sciences, University of Agriculture Faisalabad, Faisalabad, Pakistan and Department of Food Science and Agro-Industry, UniLaSalle – Campus de Rouen, Mont-Saint-Aignan, France)
Adnan Khaliq (National Institute of Food Science and Technology, Faculty of Food, Nutrition and Home Sciences, University of Agriculture Faisalabad, Faisalabad, Pakistan, and Department of Food Science and Technology, Faculty of Engineering and Technology, Khwaja Fareed University of Engineering and Information Technology, Rahim Yar Khan, Pakistan)
Farhan Jahangir Chughtai (National Institute of Food Science and Technology, Faculty of Food, Nutrition and Home Sciences, University of Agriculture Faisalabad, Faisalabad, Pakistan and Department of Food Science and Technology, Faculty of Engineering and Technology, Khwaja Fareed University of Engineering and Information Technology, Rahim Yar Khan, Pakistan)
Atif Liaqat (National Institute of Food Science and Technology, Faculty of Food, Nutrition and Home Sciences, University of Agriculture Faisalabad, Faisalabad, Pakistan and Department of Food Science and Technology, Faculty of Engineering and Technology, Khwaja Fareed University of Engineering and Information Technology, Rahim Yar Khan, Pakistan)

Nutrition & Food Science

ISSN: 0034-6659

Article publication date: 30 August 2021

Issue publication date: 7 February 2022

102

Abstract

Purpose

Innovative health-promoting approaches of the era have verified phytoceutics as one of the prime therapeutic tools to alleviate numerous health-related ailments. The purpose of this paper is to probe the nutraceutic potential of ginger flowers and leaves against hyperglycemia.

Design/methodology/approach

The aqueous extracts of ginger flowers and leaves were observed on Sprague Dawley rats for 8 weeks. Two parallel studies were carried out based on dietary regimes: control and hyperglycemic diets. At the end of the experimental modus, the overnight fed rats were killed to determine the concentration of glucose and insulin in serum. The insulin resistance and insulin secretions were also calculated by formulae by considering fasting glucose and fasting insulin concentrations. Furthermore, the feed and drink intakes, body weight gain and hematological analysis were also carried out.

Findings

In streptozotocin-induced hyperglycemic rats, the ginger flowers extract depicted 5.62% reduction; however, ginger leaves extract reduced the glucose concentration up to 7.11% (p = 0.001). Similarly, ginger flowers extract uplifted the insulin concentration up to 3.07%, while, by ginger leaves extract, the insulin value increased to 4.11% (p = 0.002). For the insulin resistance, the ginger flower showed 5.32% decrease; however, the insulin resistance was reduced to 6.48% by ginger leaves (p = 0.014). Moreover, the insulin secretion increased to 18.9% by flower extract and 21.8% by ginger leave extract (p = 0.001). The feed intake and body weight gain increased momentously by the addition of ginger flowers and leaves; however, the drink intake and hematological analysis remained non-significant by the addition of ginger parts.

Originality/value

Conclusively, it was revealed that leaves have more hypoglycemic potential as compared to flowers.

Keywords

Citation

Tanweer, S., Mehmood, T., Zainab, S., Ahmad, Z., Khan, M.A., Shehzad, A., Khaliq, A., Chughtai, F.J. and Liaqat, A. (2022), "The prophylactic potential of Zingiber officinale flowers and leaves extract to mitigate hyperglycemia in Sprague Dawley rats", Nutrition & Food Science, Vol. 52 No. 2, pp. 225-239. https://doi.org/10.1108/NFS-02-2021-0069

Publisher

:

Emerald Publishing Limited

Copyright © 2021, Emerald Publishing Limited

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