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Effects of green coffee extract supplementation on level of chemerin, malondialdehyde, nutritional and metabolic status in patients with metabolic syndrome

Mehdi Fasihi (Tabriz University of Medical Sciences, Tabriz, Islamic Republic of Iran)
Mohammad Yousefi (Tabriz University of Medical Sciences, Tabriz, Islamic Republic of Iran)
Abdolrasoul Safaiyan (Tabriz University of Medical Sciences, Tabriz, Islamic Republic of Iran)
Mahdi Mousavi Mele (Tabriz University of Medical Sciences, Tabriz, Islamic Republic of Iran)
Mohammadreza Rostami (Tabriz University of Medical Sciences, Tabriz, Islamic Republic of Iran)
Ali Barzegar (Tabriz University of Medical Sciences, Tabriz, Islamic Republic of Iran)

Nutrition & Food Science

ISSN: 0034-6659

Article publication date: 9 July 2019

Issue publication date: 22 January 2020

Abstract

Purpose

The purpose of this paper is to examine the effect of green coffee extract on anthropometric index and lipid profile, fasting blood sugar, chemerin and malondialdehyde on subjects with metabolic syndrome.

Design/methodology/approach

A randomized, double-blind, placebo-controlled clinical trial was conducted in Sheikh Al Raise Clinic from September 2016 to March 2017. The participants were randomly divided into green coffee group and placebo group. Green coffee group (n = 24) received green coffee extract (GCE), while placebo group (n = 24) took cellulose as a placebo, two capsules (400 mg) two times each day for eight weeks. The anthropometric index and lipid profile, fasting blood sugar, chemerin and malondialdehyde were measured at the beginning of the study and after eight weeks of treatment with GCE. Blood samples were collected before and after eight weeks of supplementation.

Findings

Significant weight loss, from 84.80 ± 2.12 kg to 80.94 ± 2.10 kg (ptime = 0.030, pGC = 0.007), as well as decreases in body mass index (ptime = 0.034, pGC = 0.006) were detected in the green coffee group after eight weeks. Also, the green coffee group has significant lower (pgroup = 0.029, ptime = 0.013) malondialdehyde (MDA) compared to the placebo group, and there was a significant difference between two groups at the insulin level and homeostatic model assessment of insulin resistance (HOMA-IR) (ptime = 0.001, pgroup = 0.048), (ptime = 0.012, pgroup = 0.007). However, there was no significant difference in lipid profile, fasting blood sugar and serum chemerin between two groups after eight weeks of supplementation.

Originality/value

This paper showed the statistical difference in body weight, malondialdehyde, insulin and insulin resistance after eight weeks of treatment. GCE might be associated to reduction in the carbohydrate absorption and the enhancement of lipid metabolism.

Keywords

Acknowledgements

This study was supported by the University of Medical Sciences, Tabriz, Iran (Grant T/A/104, 2016/03/12). Authors wish to honestly thank the staff of Sheikh Al Raise Clinic for their support.

Citation

Fasihi, M., Yousefi, M., Safaiyan, A., Mousavi Mele, M., Rostami, M. and Barzegar, A. (2020), "Effects of green coffee extract supplementation on level of chemerin, malondialdehyde, nutritional and metabolic status in patients with metabolic syndrome", Nutrition & Food Science, Vol. 50 No. 1, pp. 21-33. https://doi.org/10.1108/NFS-02-2019-0047

Publisher

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Emerald Publishing Limited

Copyright © 2019, Emerald Publishing Limited