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Multi-scale pulsatile CFD modeling of thrombus transport in a patient-specific LVAD implantation

Ray O. Prather (Department of Mechanical and Aerospace Engineering, University of Central Florida, Orlando, Florida, USA)
Alain Kassab (Department of Mechanical and Aerospace Engineering, University of Central Florida, Orlando, Florida, USA)
Marcus William Ni (Department of Mechanical and Aerospace Engineering, University of Central Florida, Orlando, Florida, USA)
Eduardo Divo (Department of Mechanical Engineering, Embry-Riddle Aeronautical University, Daytona Beach, Florida, USA)
Ricardo Argueta-Morales (Arnold Palmer Hospital for Children, Orlando, Florida, USA)
William M. DeCampli (College of Medicine, University of Central Florida, Orlando, Florida, USA and Arnold Palmer Hospital for Children, Orlando, Florida, USA)

International Journal of Numerical Methods for Heat & Fluid Flow

ISSN: 0961-5539

Article publication date: 2 May 2017

372

Abstract

Purpose

Predictive models implemented in medical procedures can potentially bring great benefit to patients and represent a step forward in targeted treatments based on a patient’s physiological condition. It is the purpose of this paper to outline such a model.

Design/methodology/approach

A multi-scale 0D-3D model based on patient specific geometry combines a 0-dimensional lumped parameter model (LPM) with a 3D computational fluid dynamics (CFD) analysis coupled in time, to obtain physiologically viable flow parameters.

Findings

A comparison of physiological data gathered from literature with flow-field measurements in this model shows the viability of this method in relation to potential predictions of pathological flows repercussions and candidate treatments.

Research limitations/implications

A limitation of the model is the absence of compliance in the walls in the CFD fluid domain; however, compliance of the peripheral vasculature is accounted for by the LPM. Currently, an attempt is in progress to extend this multi-scale model to account for the fluid-structure interaction of the ventricular assist device vasculature and hemodynamics.

Originality/value

This work reports on a predictive pulsatile flow model that can be used to investigate surgical alternatives to reduce strokes in LVADs.

Keywords

Citation

Prather, R.O., Kassab, A., Ni, M.W., Divo, E., Argueta-Morales, R. and DeCampli, W.M. (2017), "Multi-scale pulsatile CFD modeling of thrombus transport in a patient-specific LVAD implantation", International Journal of Numerical Methods for Heat & Fluid Flow, Vol. 27 No. 5, pp. 1022-1039. https://doi.org/10.1108/HFF-10-2016-0378

Publisher

:

Emerald Publishing Limited

Copyright © 2017, Emerald Publishing Limited

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