The incidence of prostate cancer is increasing from the past few decades. Various studies have tried to determine the survival of patients, but metastatic prostate cancer is still not extensively explored. The survival rate of metastatic prostate cancer is very less compared to the earlier stages. The study aims to investigate the survivability of metastatic prostate cancer based on the age group to which a patient belongs, and the difference between the significance of the attributes for different age groups.
Data of metastatic prostate cancer patients was collected from a cancer hospital in India. Two predictive models were built for the analysis-one for the complete dataset, and the other for separate age groups. Machine learning was applied to both the models and their accuracies were compared for the analysis. Also, information gain for each model has been evaluated to determine the significant predictors for each age group.
The ensemble approach gave the best results of 81.4% for the complete dataset, and thus was used for the age-specific models. The results concluded that the age-specific model had the direct average accuracy of 83.74% and weighted average accuracy of 79.9%, with the highest accuracy levels for age less than 60.
The study developed a model that predicts the survival of metastatic prostate cancer based on age. The study will be able to assist the clinicians in determining the best course of treatment for each patient based on ECOG, age and comorbidities.
The authors would like to thank Rajiv Gandhi Cancer Institute and Research Center, New Delhi for providing the opportunity and environment to carry out the data collection process in their premises. We are also thankful to the urology team of RGCIRC to cooperate with us and giving valuable suggestions in the process.
Doja, M.N., Kaur, I. and Ahmad, T. (2020), "Age-specific survival in prostate cancer using machine learning", Data Technologies and Applications, Vol. 54 No. 2, pp. 215-234. https://doi.org/10.1108/DTA-10-2019-0189Download as .RIS
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