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Validation of Hagerman’s behavioral phenotype for fragile X syndrome among men with intellectual disability

Jacques Bellavance (Department of Psychology, Université du Québec à Montréal, Montreal, Canada)
Morin Diane (Department of Psychology, Université du Québec à Montréal, Montreal, Canada)
Catherine Mello (Department of Psychology, The Pennsylvania State University Berks, Reading, Pennsylvania, USA)

Advances in Mental Health and Intellectual Disabilities

ISSN: 2044-1282

Article publication date: 19 June 2021

Issue publication date: 26 July 2021

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Abstract

Purpose

The behavioral phenotype of fragile X syndrome (FXS) and intellectual disability (ID) proposed by Hagerman et al. (2009) was primarily based on data from male children and teens. The purpose of this study was to promote a better understanding of how this condition manifests in adults.

Design/methodology/approach

A total of 18 men of FXS were paired with men with Down syndrome on the basis of age and level of ID. A screening checklist was created on the basis of existing scales and the Hagerman et al. (2009) behavioral phenotype and completed by care providers.

Findings

Five of the 12 features of the phenotype were significantly more present among men with FXS than in men with Down syndrome.

Originality/value

This study provides partial confirmation for Hagerman et al.’s (2009) behavioral phenotype of FXS among men with moderate ID and identified some traits that warrant further investigation.

Keywords

Acknowledgements

Consortium national de recherche sur l’intégration sociale and the Chaire de déficience intellectuelle et troubles du comportement. Financial Support.

Citation

Bellavance, J., Diane, M. and Mello, C. (2021), "Validation of Hagerman’s behavioral phenotype for fragile X syndrome among men with intellectual disability", Advances in Mental Health and Intellectual Disabilities, Vol. 15 No. 2/3, pp. 66-78. https://doi.org/10.1108/AMHID-09-2020-0020

Publisher

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Emerald Publishing Limited

Copyright © 2021, Emerald Publishing Limited

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