TY  - JOUR
AB  - Purpose Diagnosing pain and pain inflicting diseases are crucial issues in the health care of individuals with intellectual and developmental disabilities. The purpose of this paper is to delineate possible peculiarities in pain perception, characterizing a syndrome-specific spectrum of pain causing diseases as well as particular features of pain expression in Rett syndrome (RTT).Design/methodology/approach A selective review of the literature on pain, dolorous disorders and diseases, molecular aspects of pain transduction, pain perception, and expression of painful conditions in RTT was undertaken.Findings RTT causing mutations in the methyl-CpG-binding protein 2 (MECP2) have an impact on various endogenous molecules modulating pain transmission. Individuals with RTT are specifically prone to numerous pathological states which can cause pain. By thorough observation/application of proper tools, it is possible to recognize painful states in persons with RTT.Originality/value This paper imparts empirical/evidence-based data on pain perception/transmission, possible syndrome-specific causes of pain and pain expression/assessment in RTT, with the objective of promoting the quality of clinical practice in this crucial issue.
VL  - 3
IS  - 3
SN  - 2056-3868
DO  - 10.1108/AIA-02-2017-0003
UR  - https://doi.org/10.1108/AIA-02-2017-0003
AU  - Martin Peter
PY  - 2017
Y1  - 2017/01/01
TI  - Pain in Rett syndrome: peculiarities in pain processing and expression, liability to pain causing disorders and diseases, and specific aspects of pain assessment
T2  - Advances in Autism
PB  - Emerald Publishing Limited
SP  - 163
EP  - 182
Y2  - 2024/09/24
ER  -