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Fabrication of a biodegradable drug delivery system with controlled release made of PLGA/5‐FU/hydroxyapatite

Won‐Shik Chu (School of Mechanical and Aerospace Engineering, Seoul National University, Seoul, South Korea)
Suk‐Young Jeong (School of Mechanical and Aerospace Engineering, Seoul National University, Seoul, South Korea)
Sung‐Geun Kim (School of Mechanical and Aerospace Engineering, Seoul National University, Seoul, South Korea)
Won‐Shik Ha (College of Pharmacy, Sungkyunkwan University, Suwon, South Korea)
Sang‐Chul Chi (College of Pharmacy, Sungkyunkwan University, Suwon, South Korea)
Sung‐Hoon Ahn (School of Mechanical and Aerospace Engineering, Seoul National University, Seoul, South Korea)

Rapid Prototyping Journal

ISSN: 1355-2546

Article publication date: 26 September 2008

1530

Abstract

Purpose

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Rapid prototyping (RP) technology has been widely applied in biomedical research. The purpose of this paper is to describe how a scaffold composite drug delivery system (DDS) was fabricated using a nano composite deposition system (NCDS).

Design/methodology/approach

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A biocompatible and biodegradable thermoplastic polymer (poly(DL‐lactide‐co‐glycolide acid)) was used as the matrix, and a mixture of anti‐cancer drug (5‐fluorouracil) and bio‐ceramic (hydroxyapatite – HA) was added to the polymer to form a bio‐composite material for the DDS. An in vitro drug release test showed that the release rate of the drug composite could be controlled by the amount of HA for 50 days.

Findings

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Faster release was observed for the DDS with higher weight percent of HA. The relationship between release rate and the amount of HA showed a bi‐linear manner, and bi‐linear drug release models were developed based on the experimental results.

Originality/value

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Cylindrical scaffolds were fabricated with polymer/drug/additive using an NCDS. A series of in vitro drug release tests was performed to evaluate the effectiveness of the additive, HA. Drug release models were developed based on the experimental results.

Keywords

Citation

Chu, W., Jeong, S., Kim, S., Ha, W., Chi, S. and Ahn, S. (2008), "Fabrication of a biodegradable drug delivery system with controlled release made of PLGA/5‐FU/hydroxyapatite", Rapid Prototyping Journal, Vol. 14 No. 5, pp. 293-299. https://doi.org/10.1108/13552540810907965

Publisher

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Emerald Group Publishing Limited

Copyright © 2008, Emerald Group Publishing Limited

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