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Use of slow release starch (SRS) to treat hypoglycaemia in type 1 diabetics

Xin Qi (Glycologic Limited, c/o Glasgow Caledonian University, Glasgow, UK)
Margaret Band (Department of Endocrinology, UCLH, London, UK)
Richard Tester (Glycologic Limited, c/o Glasgow Caledonian University, Glasgow, UK)
John Piggott (Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK)
Steve J. Hurel (Department of Endocrinology, UCLH, London, UK)

Nutrition & Food Science

ISSN: 0034-6659

Article publication date: 30 March 2010

358

Abstract

Purpose

The purpose of this paper is to evaluate if slow release starch (SRS) could be used to control/limit hypoglycaemia in type 1 diabetics.

Design/methodology/approach

Ten type‐1 diabetic volunteers were fitted with continuous glucose monitors for two periods of 3 days when undertaking their normal routine or when consuming 60 g SRS before sleep.

Findings

The average number of nocturnal hypoglycaemic episodes where no SRS was consumed over 3 days was 2.7 ± 2.0 but only 0.7 ± 1.1 after SRS consumption before sleep. The duration of these events was equivalent to 318 ± 282 and 140 ± 337 min, respectively. Average nocturnal blood glucose concentration was 7.9 ± 1.4 mmol l−1 without SRS consumption but increased to 9.7 ± 2.7 mmol l−1 when SRS was consumed. These data were highly significant when subjected to analysis of variance (ANOVA) test on a subject by subject basis. The SRS may be used as a cost effective therapy to avoid hypoglycaemia in patients with type‐1 diabetes.

Originality/value

This paper reports for the first time the use of a physically modified waxy maize starch (SRS) to prevent/limit the incidence of nocturnal hypoglycaemia in type 1 diabetics.

Keywords

Citation

Qi, X., Band, M., Tester, R., Piggott, J. and Hurel, S.J. (2010), "Use of slow release starch (SRS) to treat hypoglycaemia in type 1 diabetics", Nutrition & Food Science, Vol. 40 No. 2, pp. 228-234. https://doi.org/10.1108/00346651011029264

Publisher

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Emerald Group Publishing Limited

Copyright © 2010, Emerald Group Publishing Limited

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