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Efficacy of Ganoderma lucidum on plasma lipids and lipoproteins in rats fed with high cholesterol diet

Chow‐Chin Tong (Department of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Selangor, Malaysia)
Yew‐Keong Choong (Department of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Selangor, Malaysia)
Suhaila Mohamed (Department of Food Service and Management, Faculty of Food Science and Technology, Universiti Putra Malaysia, Selangor, Malaysia)
Noordin Mohamed Mustapha (Department of Pathology and Veterinary Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Selangor, Malaysia, and)
Nor Aini Umar (Department of Pathology, Hospital Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia)

Nutrition & Food Science

ISSN: 0034-6659

Article publication date: 23 May 2008

Abstract

Purpose

The purpose of this paper is to report on the anti‐cholesterol activities of Ganoderma lucidum on Sprague–Dawley white rats.

Design/methodology/approach

Rats were divided into four groups with a sample size of six rats per groups. Different formula diets were given to each group for a period of six months. At regular intervals, blood samples were taken and analysed for the total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL‐C) and low density lipoprotein (LDL‐C) levels.

Findings

Administration of hyperlipidemia diet in rats fed with 1 per cent cholesterol diet caused an increase in the TC, TG, as well as LDL‐C level as compared to the control. A decrease of 23.6 per cent in the HDL‐C level was also noted. However, supplementation of the feed with G. lucidum (0.1 per cent) in rats decreased the TC, TG and LDL‐C level significantly (P < 0.05) while further increased the plasma concentration of HDL‐C. In the case of rats fed with diet containing a mixture of 1 per cent cholesterol and 0.1 per cent of Ganoderma, the lipid profile showed much higher readings (p < 0.05) compared to the chol group.

Practical implications

The possible efficacy of G. lucidum in reducing the deposition of cholesterol in the wall of the blood vessels was indicated.

Originality/value

This article provides useful information to health care providers and consumers.

Keywords

Citation

Tong, C., Choong, Y., Mohamed, S., Mohamed Mustapha, N. and Aini Umar, N. (2008), "Efficacy of Ganoderma lucidum on plasma lipids and lipoproteins in rats fed with high cholesterol diet", Nutrition & Food Science, Vol. 38 No. 3, pp. 229-238. https://doi.org/10.1108/00346650810871911

Publisher

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Emerald Group Publishing Limited

Copyright © 2008, Emerald Group Publishing Limited