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Transcending tradition: Quality of life as the inextricable link between activities of daily living and specific organ and disease states

The Value of Innovation: Impact on Health, Life Quality, Safety, and Regulatory Research

ISBN: 978-0-7623-1346-4, eISBN: 978-1-84950-551-2

ISSN: 0194-3960

Publication date: 1 November 2007

Abstract

We review the conceptualization of quality of life (QOL) past and present, providing a new definition that transcends the traditional approach. We discuss the importance of QOL as a mandatory assessment in patient care and clinical trials, concurring with the need for disease-specific tools and focusing on a nerve fiber-specific tool for assessing impacts of diabetic neuropathies on QOL and activities of daily living (ADLs) used in multi-center clinical trials and translated into different languages. By relating neuropathic disabilities to different nerve fibers, the Norfolk Quality of Life – Diabetic Neuropathy (QOL-DN) is able to measure impacts of nerve-fiber-specific neurotrophic therapies, providing pertinent endpoints to changes in health status and QOL.

Citation

Vinik, E.J. and Vinik, A.I. (2007), "Transcending tradition: Quality of life as the inextricable link between activities of daily living and specific organ and disease states", Farquhar, I., Summers, K.H. and Sorkin, A. (Ed.) The Value of Innovation: Impact on Health, Life Quality, Safety, and Regulatory Research (Research in Human Capital and Development, Vol. 16), Emerald Group Publishing Limited, Bingley, pp. 29-52. https://doi.org/10.1016/S0194-3960(08)16002-4

Publisher

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Emerald Group Publishing Limited

Copyright © 2008, Emerald Group Publishing Limited